CTLA-4 polymorphisms and susceptibility to Behcet's disease: a meta-analysis
- Authors
- Lee, Young Ho; Song, Gwan Gyu
- Issue Date
- 9월-2012
- Publisher
- SPRINGER
- Keywords
- Behcet' s disease; Cytotoxic T lymphocyte antigen-4; Polymorphism; Meta-analysis
- Citation
- MOLECULAR BIOLOGY REPORTS, v.39, no.9, pp.9041 - 9045
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULAR BIOLOGY REPORTS
- Volume
- 39
- Number
- 9
- Start Page
- 9041
- End Page
- 9045
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/107576
- DOI
- 10.1007/s11033-012-1775-9
- ISSN
- 0301-4851
- Abstract
- The aim of this study was to explore whether cytotoxic T lymphocyte antigen-4 (CTLA-4) polymorphisms confer susceptibility to Behcet's disease (BD). A meta-analysis was conducted on the associations between the CTLA-4 +49 A/G, -318 C/T, CT60 A/G polymorphisms and BD using; (1) allele contrast, (2) the recessive model, (3) the dominant model, and (4) the additive model. A total of 8 separate comparison studies on BD were considered in the meta-analysis. Meta-analysis of the CTLA-4 +49 A/G polymorphisms showed no association between BD and the CTLA-4 +49 G allele in all study subjects (odds ratio [OR] = 0.780, 95 % confidence interval [CI] = 0.491-1.240, p = 0.294). Moreover, stratification by ethnicity indicated no association between the CTLA-4 +49 G allele and BD in Turkish population. No association was found between BD and the CTLA-4 +49 A/G polymorphisms using recessive or dominant models or contrast of homozygotes. No association was found between BD and the CTLA-4 -318 C/T or CT60 A/G polymorphisms. This meta-analysis showed that no association was found between CTLA-4 +49 A/G, -318 C/T or CT60 A/G polymorphisms and BD.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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