Do microRNA 96, 145 and 221 expressions really aid in the prognosis of prostate carcinoma?
DC Field | Value | Language |
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dc.contributor.author | Kang, Sung Gu | - |
dc.contributor.author | Ha, Young Ran | - |
dc.contributor.author | Kim, Seo Jin | - |
dc.contributor.author | Kang, Seok Ho | - |
dc.contributor.author | Park, Hong Seok | - |
dc.contributor.author | Lee, Jeong Gu | - |
dc.contributor.author | Cheon, Jun | - |
dc.contributor.author | Kim, Chul Hwan | - |
dc.date.accessioned | 2021-09-06T16:08:50Z | - |
dc.date.available | 2021-09-06T16:08:50Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 1008-682X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/107598 | - |
dc.description.abstract | MicroRNAs (miRs) are small noncoding RNAs that have been reported to be promising diagnostic tools. We used quantitative real-time reverse transcription PCR (RT-qPCR) to analyze differentially expressed miRNAs in prostate tumor samples to determine its prognostic value. From 2007 to 2009, tumor tissues were obtained from 73 radical prostatectomy specimens. Differentially expressed miR-96, -145 and -221 were validated by TaqMan RT-qPCR using all 73 tissues. The prognostic value was assessed in terms of biochemical recurrence using Kaplan-Meier and Cox regression analyses. For our patient cohort, the mean age was 64.7 years (50-76 years) and the mean prostate-specific antigen (PSA) was 7.5 ng ml(-1). During the follow-up period (mean, 19.4 months), 14 of 73 (19.2%) patients developed biochemical recurrence. Expression of miR-96, -145 and -221 correlated strongly with each other, but there were no correlations between miRNA expression and clinicopathologic parameters. Kaplan-Meier survival curves using the log-rank test showed a decreased biochemical recurrence-free interval with pathologic stage (P<0.001). In addition, patients with Gleason scores over 8, compared with those with a Gleason score of 6, showed a decreased biochemical recurrence-free interval in Kaplan-Meier analysis (P=0.001). However, expression of miR-96, -145 and -221 did not correlate with the biochemical recurrence interval in Kaplan-Meier survival curves or by multivariate analysis using the Cox proportional hazard regression model, either. In conclusion, we did not observe a significant correlation between the expression of miR-96, -145 and -221 and clinicopathologic parameters. To utilize miRNA as a diagnostic tool in clinical practice, more research is needed to understand miRNA mechanisms, identify miRNA targets, and further characterize miRNA function. Asian Journal of Andrology (2012) 14, 752-757; doi:10.1038/aja.2012.68; published online 6 August 2012 | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACTA PHARMACOLOGICA SINICA | - |
dc.subject | BREAST-CANCER | - |
dc.subject | TUMOR INVASION | - |
dc.subject | METASTASIS | - |
dc.subject | DEREGULATION | - |
dc.subject | PROFILES | - |
dc.title | Do microRNA 96, 145 and 221 expressions really aid in the prognosis of prostate carcinoma? | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Sung Gu | - |
dc.contributor.affiliatedAuthor | Kang, Seok Ho | - |
dc.contributor.affiliatedAuthor | Park, Hong Seok | - |
dc.contributor.affiliatedAuthor | Lee, Jeong Gu | - |
dc.contributor.affiliatedAuthor | Cheon, Jun | - |
dc.contributor.affiliatedAuthor | Kim, Chul Hwan | - |
dc.identifier.doi | 10.1038/aja.2012.68 | - |
dc.identifier.scopusid | 2-s2.0-84866241357 | - |
dc.identifier.wosid | 000308666400021 | - |
dc.identifier.bibliographicCitation | ASIAN JOURNAL OF ANDROLOGY, v.14, no.5, pp.752 - 757 | - |
dc.relation.isPartOf | ASIAN JOURNAL OF ANDROLOGY | - |
dc.citation.title | ASIAN JOURNAL OF ANDROLOGY | - |
dc.citation.volume | 14 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 752 | - |
dc.citation.endPage | 757 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Andrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | TUMOR INVASION | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | DEREGULATION | - |
dc.subject.keywordPlus | PROFILES | - |
dc.subject.keywordAuthor | microRNA | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | prostate cancer | - |
dc.subject.keywordAuthor | recurrence | - |
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