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Subacute inhalation toxicity assessment of fly ash from industrial waste incinerators

Authors
Shim, IlseobOh, EunhaYang, SangyoungRyu, TaekwonSoh, JaewonSul, DonggeunKim, Pilje
Issue Date
9월-2012
Publisher
INFORMA HEALTHCARE
Keywords
Comet assay; fly ash; heavy metals; inhalation; lipid peroxidation
Citation
INHALATION TOXICOLOGY, v.24, no.11, pp.741 - 750
Indexed
SCIE
SCOPUS
Journal Title
INHALATION TOXICOLOGY
Volume
24
Number
11
Start Page
741
End Page
750
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/107618
DOI
10.3109/08958378.2012.716869
ISSN
0895-8378
Abstract
Fly ash from industrial waste incinerators has been a significant concern because of their constituent toxic heavy metals and organic compounds. The objective of this study was to identify the subacute inhalation toxicity of fly ash from industrial waste incinerators, using whole body inhalation exposure chambers. Male and female groups of Sprague-Dawley rats were exposed to fly ash by inhalation of concentrations of 0, 50, 100, 200 mg/m(3), for 6 h/day, 5 days/week for 4 weeks. There was no significant difference in body weight, and relative organ weight to body weight, between the exposure groups and the control group. Hematological examinations revealed a significant increase of monocyte counts in fly ash exposed rats and brown pigment laden macrophage was found in the lungs of rats exposed to high concentration of fly ash. A decrease of blood glucose levels and an increase in glutamate oxaloacetate transaminase activity were observed in fly ash treated rats. There was also a significant increase of lactate dehydrogenase levels in rat blood exposed fly ash. A significant dose-dependent increase of DNA damage was found in lymphocytes, spleen, bronchoalveolar lavage, liver, lung, and thymus of rats exposed to fly ash. In addition, the level of lipid peroxidation was increased in the plasma of rats exposed to a high concentration of fly ash. These results suggest that inhalation of fly ash from industrial waste incinerators can induce histopathologic, hematological, and serum biochemical changes and oxidative damage.
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