Associations between PXK and TYK2 polymorphisms and systemic lupus erythematosus: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-06T16:13:01Z | - |
dc.date.available | 2021-09-06T16:13:01Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 1023-3830 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/107622 | - |
dc.description.abstract | The aim of this study was to determine whether phox homology domain containing serine/threonine kinase (PXK) and tyrosine kinase 2 (TYK2) confer susceptibility to systemic lupus erythematosus (SLE). The authors conducted meta-analyses on associations between SLE susceptibility and the rs6445975 polymorphism of PXK and the rs2304256, rs12720270, rs280519, and rs1272036 polymorphisms of TYK2. A total of 13 separate comparisons studies were included in this meta-analysis. Meta-analysis identified an association between SLE and the 2 allele of the rs6445975 polymorphism in the overall population [odds ratio (OR) = 1.151, 95 % confidence interval (CI) = 1.086-1.291, P = 1.8E-06]. Stratification by ethnicity identified a significant association between this polymorphism and SLE in Europeans (OR = 1.198, 95 % CI = 1.118-1.285, P = 3.4E-07), but not in Asians. Meta-analysis identified a significant negative association between SLE and the 2 allele of the rs2304256 polymorphism in the overall population (OR = 0.808, 95 % CI = 0.659-0.990, P = 0.040), and a significant negative association was found in Europeans, but not in Asians. This meta-analysis shows that the rs6445975 polymorphism of PXK and the rs2304256 polymorphism of TYK2 are associated with the development of SLE in Europeans. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER BASEL AG | - |
dc.subject | TYROSINE KINASE | - |
dc.subject | SLE SUSCEPTIBILITY | - |
dc.subject | GENE POLYMORPHISMS | - |
dc.subject | CHINESE | - |
dc.subject | POPULATION | - |
dc.subject | EXPRESSION | - |
dc.subject | BINDING | - |
dc.subject | SCAN | - |
dc.subject | IRF5 | - |
dc.subject | LOCI | - |
dc.title | Associations between PXK and TYK2 polymorphisms and systemic lupus erythematosus: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1007/s00011-012-0486-y | - |
dc.identifier.scopusid | 2-s2.0-84865149814 | - |
dc.identifier.wosid | 000307517300005 | - |
dc.identifier.bibliographicCitation | INFLAMMATION RESEARCH, v.61, no.9, pp.949 - 954 | - |
dc.relation.isPartOf | INFLAMMATION RESEARCH | - |
dc.citation.title | INFLAMMATION RESEARCH | - |
dc.citation.volume | 61 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 949 | - |
dc.citation.endPage | 954 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | TYROSINE KINASE | - |
dc.subject.keywordPlus | SLE SUSCEPTIBILITY | - |
dc.subject.keywordPlus | GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | CHINESE | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | SCAN | - |
dc.subject.keywordPlus | IRF5 | - |
dc.subject.keywordPlus | LOCI | - |
dc.subject.keywordAuthor | Phox homology domain containing serine/threonine kinase | - |
dc.subject.keywordAuthor | Tyrosine kinase 2 | - |
dc.subject.keywordAuthor | Polymorphisms | - |
dc.subject.keywordAuthor | Systemic lupus erythematosus | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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