Associations between PXK and TYK2 polymorphisms and systemic lupus erythematosus: a meta-analysis
- Authors
- Lee, Young Ho; Choi, Sung Jae; Ji, Jong Dae; Song, Gwan Gyu
- Issue Date
- 9월-2012
- Publisher
- SPRINGER BASEL AG
- Keywords
- Phox homology domain containing serine/threonine kinase; Tyrosine kinase 2; Polymorphisms; Systemic lupus erythematosus; Meta-analysis
- Citation
- INFLAMMATION RESEARCH, v.61, no.9, pp.949 - 954
- Indexed
- SCIE
SCOPUS
- Journal Title
- INFLAMMATION RESEARCH
- Volume
- 61
- Number
- 9
- Start Page
- 949
- End Page
- 954
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/107622
- DOI
- 10.1007/s00011-012-0486-y
- ISSN
- 1023-3830
- Abstract
- The aim of this study was to determine whether phox homology domain containing serine/threonine kinase (PXK) and tyrosine kinase 2 (TYK2) confer susceptibility to systemic lupus erythematosus (SLE). The authors conducted meta-analyses on associations between SLE susceptibility and the rs6445975 polymorphism of PXK and the rs2304256, rs12720270, rs280519, and rs1272036 polymorphisms of TYK2. A total of 13 separate comparisons studies were included in this meta-analysis. Meta-analysis identified an association between SLE and the 2 allele of the rs6445975 polymorphism in the overall population [odds ratio (OR) = 1.151, 95 % confidence interval (CI) = 1.086-1.291, P = 1.8E-06]. Stratification by ethnicity identified a significant association between this polymorphism and SLE in Europeans (OR = 1.198, 95 % CI = 1.118-1.285, P = 3.4E-07), but not in Asians. Meta-analysis identified a significant negative association between SLE and the 2 allele of the rs2304256 polymorphism in the overall population (OR = 0.808, 95 % CI = 0.659-0.990, P = 0.040), and a significant negative association was found in Europeans, but not in Asians. This meta-analysis shows that the rs6445975 polymorphism of PXK and the rs2304256 polymorphism of TYK2 are associated with the development of SLE in Europeans.
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