Biomarkers and location of atherosclerosis: Matrix metalloproteinase-2 may be related to intracranial atherosclerosis
DC Field | Value | Language |
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dc.contributor.author | Jeon, Sang-Beom | - |
dc.contributor.author | Chun, Sail | - |
dc.contributor.author | Choi-Kwon, Smi | - |
dc.contributor.author | Chi, Hyun-Sook | - |
dc.contributor.author | Nah, Hyun-Wook | - |
dc.contributor.author | Kwon, Sun U. | - |
dc.contributor.author | Kim, Won-Ki | - |
dc.contributor.author | Kim, Jong S. | - |
dc.date.accessioned | 2021-09-06T17:02:37Z | - |
dc.date.available | 2021-09-06T17:02:37Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.issn | 0021-9150 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/107761 | - |
dc.description.abstract | Background: Various biomarkers are linked with the pathophysiology of atherosclerosis. We hypothesized that these factors may be associated with the location and burden of cerebral atherosclerosis. Methods: We evaluated 177 consecutive patients with chronic (>6 months) ischemic stroke: 68 with small vessel occlusion (SVO) and 109 with large-artery atherosclerosis (LAA), with the latter further sub-classified into 80 patients with intracranial atherosclerosis (ICAS) and 29 with extracranial atherosclerosis (ECAS). The number of >= 50% steno-occlusions on magnetic resonance angiography was used to assess the burden of atherosclerosis. Serum concentrations of the biomarkers (matrix metalloproteinases (MMP)-2 and -9, homocysteine, interleukin (IL)-6, tumor necrosis factor-alpha, C-reactive protein, adiponectin, leptin, resistin, free fatty acid, and lipoprotein(a)) and the metabolic syndrome were measured in each study subject. Results: Decreased plasma concentrations of MMP-2 (p = 0.020) and homocysteine (p = 0.038) were more closely associated with ICAS than with ECAS, whereas increased IL-6 concentrations were related to severe (>= 4 steno-occlusions) atherosclerosis (p = 0.031). Multiple logistic regression analysis showed that the lowest tertile of MMP-2 was independently associated with ICAS (OR 4.84, 95% CI 1.29-18.19, p = 0.022). Conclusion: Low MMP-2 plasma levels are associated with intracranial location of cerebral atherosclerosis, suggesting that MMP-2 may play a role in the development of ICAS. (C) 2012 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | PLASMA HOMOCYST(E)INE | - |
dc.subject | ISCHEMIC-STROKE | - |
dc.subject | CEREBRAL ATHEROSCLEROSIS | - |
dc.subject | HOMOCYSTEINE | - |
dc.subject | INFARCTION | - |
dc.subject | DISEASE | - |
dc.subject | LESIONS | - |
dc.subject | ROLES | - |
dc.subject | RISK | - |
dc.title | Biomarkers and location of atherosclerosis: Matrix metalloproteinase-2 may be related to intracranial atherosclerosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Won-Ki | - |
dc.identifier.doi | 10.1016/j.atherosclerosis.2012.04.013 | - |
dc.identifier.scopusid | 2-s2.0-84864762421 | - |
dc.identifier.wosid | 000307239800031 | - |
dc.identifier.bibliographicCitation | ATHEROSCLEROSIS, v.223, no.2, pp.442 - 447 | - |
dc.relation.isPartOf | ATHEROSCLEROSIS | - |
dc.citation.title | ATHEROSCLEROSIS | - |
dc.citation.volume | 223 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 442 | - |
dc.citation.endPage | 447 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | PLASMA HOMOCYST(E)INE | - |
dc.subject.keywordPlus | ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | CEREBRAL ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | HOMOCYSTEINE | - |
dc.subject.keywordPlus | INFARCTION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | LESIONS | - |
dc.subject.keywordPlus | ROLES | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | Atherosclerosis | - |
dc.subject.keywordAuthor | Biological markers | - |
dc.subject.keywordAuthor | Matrix metalloproteinase | - |
dc.subject.keywordAuthor | Interkeukin-6 | - |
dc.subject.keywordAuthor | Homocysteine | - |
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