Biomarkers and location of atherosclerosis: Matrix metalloproteinase-2 may be related to intracranial atherosclerosis
- Authors
- Jeon, Sang-Beom; Chun, Sail; Choi-Kwon, Smi; Chi, Hyun-Sook; Nah, Hyun-Wook; Kwon, Sun U.; Kim, Won-Ki; Kim, Jong S.
- Issue Date
- 8월-2012
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Atherosclerosis; Biological markers; Matrix metalloproteinase; Interkeukin-6; Homocysteine
- Citation
- ATHEROSCLEROSIS, v.223, no.2, pp.442 - 447
- Indexed
- SCIE
SCOPUS
- Journal Title
- ATHEROSCLEROSIS
- Volume
- 223
- Number
- 2
- Start Page
- 442
- End Page
- 447
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/107761
- DOI
- 10.1016/j.atherosclerosis.2012.04.013
- ISSN
- 0021-9150
- Abstract
- Background: Various biomarkers are linked with the pathophysiology of atherosclerosis. We hypothesized that these factors may be associated with the location and burden of cerebral atherosclerosis. Methods: We evaluated 177 consecutive patients with chronic (>6 months) ischemic stroke: 68 with small vessel occlusion (SVO) and 109 with large-artery atherosclerosis (LAA), with the latter further sub-classified into 80 patients with intracranial atherosclerosis (ICAS) and 29 with extracranial atherosclerosis (ECAS). The number of >= 50% steno-occlusions on magnetic resonance angiography was used to assess the burden of atherosclerosis. Serum concentrations of the biomarkers (matrix metalloproteinases (MMP)-2 and -9, homocysteine, interleukin (IL)-6, tumor necrosis factor-alpha, C-reactive protein, adiponectin, leptin, resistin, free fatty acid, and lipoprotein(a)) and the metabolic syndrome were measured in each study subject. Results: Decreased plasma concentrations of MMP-2 (p = 0.020) and homocysteine (p = 0.038) were more closely associated with ICAS than with ECAS, whereas increased IL-6 concentrations were related to severe (>= 4 steno-occlusions) atherosclerosis (p = 0.031). Multiple logistic regression analysis showed that the lowest tertile of MMP-2 was independently associated with ICAS (OR 4.84, 95% CI 1.29-18.19, p = 0.022). Conclusion: Low MMP-2 plasma levels are associated with intracranial location of cerebral atherosclerosis, suggesting that MMP-2 may play a role in the development of ICAS. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.