Detection of rectal cancer and response to concurrent chemoradiotherapy by proton magnetic resonance spectroscopy
DC Field | Value | Language |
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dc.contributor.author | Kim, Min Ju | - |
dc.contributor.author | Lee, Soon Jin | - |
dc.contributor.author | Lee, Jung Hee | - |
dc.contributor.author | Kim, Seung Hoon | - |
dc.contributor.author | Chun, Ho Kyung | - |
dc.contributor.author | Kim, Seong Hyun | - |
dc.contributor.author | Lim, Hyo Keun | - |
dc.contributor.author | Yun, Seong Hyeon | - |
dc.date.accessioned | 2021-09-06T18:04:42Z | - |
dc.date.available | 2021-09-06T18:04:42Z | - |
dc.date.issued | 2012-07 | - |
dc.identifier.issn | 0730-725X | - |
dc.identifier.issn | 1873-5894 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108026 | - |
dc.description.abstract | Introduction: To diagnose rectal cancer and monitor treatment response after preoperative concurrent chemoradiotherapy (CCRT) in rectal cancer patients using proton-1 magnetic resonance spectroscopy (H-1-MRS). Materials and Methods: We enrolled 134 rectal cancer patients before treatment, of whom 34 underwent preoperative CCRT and follow-up MR spectroscopy before surgery. H-1-MRS was performed using a six-channel phased-array coil at 3.0 T. We evaluated the presence of a choline peak at 3.2 ppm, and lipid peaks at 0.9 and 1.3 ppm, and glutamine and glutamate peaks at 2.1-2.3 and 2.7 ppm seen at two TEs (40 and 135 ms). We divided MR spectra patterns into two groups (A and B). Results: A choline peak at 3.2 ppm seen in both TEs was characteristic for rectal cancer before treatment. Of 103 patients, 55 (53%) showed an elevated choline peak before treatment (type A). Type A spectra were seen in 68% of patients (23/34) before preoperative CCRT. After CCRT, the choline peak disappeared, resulting in only the lipid peak at 1.3 ppm (type B) in 97% of patients (33/34). Discussion: We optimized a localized in vivo H-1-MRS method for detection of rectal adenocarcinoma and monitoring treatment response after preoperative CCRT. The method appears to be a promising and feasible noninvasive modality. (C) 2012 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Detection of rectal cancer and response to concurrent chemoradiotherapy by proton magnetic resonance spectroscopy | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.mri.2012.02.013 | - |
dc.identifier.scopusid | 2-s2.0-84861661583 | - |
dc.identifier.wosid | 000305307100010 | - |
dc.identifier.bibliographicCitation | MAGNETIC RESONANCE IMAGING, v.30, no.6, pp 848 - 853 | - |
dc.citation.title | MAGNETIC RESONANCE IMAGING | - |
dc.citation.volume | 30 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 848 | - |
dc.citation.endPage | 853 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | PHASED-ARRAY COIL | - |
dc.subject.keywordPlus | MR SPECTROSCOPY | - |
dc.subject.keywordPlus | ENDORECTAL COIL | - |
dc.subject.keywordPlus | PREOPERATIVE CHEMORADIOTHERAPY | - |
dc.subject.keywordPlus | CHEMORADIATION THERAPY | - |
dc.subject.keywordPlus | NONOPERATIVE TREATMENT | - |
dc.subject.keywordPlus | CLINICAL-APPLICATIONS | - |
dc.subject.keywordPlus | COLON TISSUE | - |
dc.subject.keywordPlus | HUMAN-TUMORS | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordAuthor | MR spectroscopy | - |
dc.subject.keywordAuthor | Rectal cancer | - |
dc.subject.keywordAuthor | Concurrent chemoradiotherapy | - |
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