Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Detection of rectal cancer and response to concurrent chemoradiotherapy by proton magnetic resonance spectroscopy

Authors
Kim, Min JuLee, Soon JinLee, Jung HeeKim, Seung HoonChun, Ho KyungKim, Seong HyunLim, Hyo KeunYun, Seong Hyeon
Issue Date
7월-2012
Publisher
ELSEVIER SCIENCE INC
Keywords
MR spectroscopy; Rectal cancer; Concurrent chemoradiotherapy
Citation
MAGNETIC RESONANCE IMAGING, v.30, no.6, pp.848 - 853
Indexed
SCIE
SCOPUS
Journal Title
MAGNETIC RESONANCE IMAGING
Volume
30
Number
6
Start Page
848
End Page
853
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/108026
DOI
10.1016/j.mri.2012.02.013
ISSN
0730-725X
Abstract
Introduction: To diagnose rectal cancer and monitor treatment response after preoperative concurrent chemoradiotherapy (CCRT) in rectal cancer patients using proton-1 magnetic resonance spectroscopy (H-1-MRS). Materials and Methods: We enrolled 134 rectal cancer patients before treatment, of whom 34 underwent preoperative CCRT and follow-up MR spectroscopy before surgery. H-1-MRS was performed using a six-channel phased-array coil at 3.0 T. We evaluated the presence of a choline peak at 3.2 ppm, and lipid peaks at 0.9 and 1.3 ppm, and glutamine and glutamate peaks at 2.1-2.3 and 2.7 ppm seen at two TEs (40 and 135 ms). We divided MR spectra patterns into two groups (A and B). Results: A choline peak at 3.2 ppm seen in both TEs was characteristic for rectal cancer before treatment. Of 103 patients, 55 (53%) showed an elevated choline peak before treatment (type A). Type A spectra were seen in 68% of patients (23/34) before preoperative CCRT. After CCRT, the choline peak disappeared, resulting in only the lipid peak at 1.3 ppm (type B) in 97% of patients (33/34). Discussion: We optimized a localized in vivo H-1-MRS method for detection of rectal adenocarcinoma and monitoring treatment response after preoperative CCRT. The method appears to be a promising and feasible noninvasive modality. (C) 2012 Elsevier Inc. All rights reserved.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Min Ju photo

Kim, Min Ju
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE