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Expression, purification, crystallization and preliminary X-ray analysis of the human NORE1 SARAH domain
- Authors
- Kim, Hye Jin; Hwang, Eunha; Han, Young-Hyun; Choi, Saehae; Lee, Woo Cheol; Kim, Hye-Yeon; Jeon, Young Ho; Cheong, Chaejoon; Cheong, Hae-Kap
- Issue Date
- 7월-2012
- Publisher
- INT UNION CRYSTALLOGRAPHY
- Keywords
- apoptosis; NORE1; Ras; tumour suppressors
- Citation
- ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, v.68, pp.813 - 815
- Indexed
- SCOPUS
- Volume
- 68
- Start Page
- 813
- End Page
- 815
- ISSN
- 2053-230X
- Abstract
- NORE1 is an important tumour suppressor in human cancers that interacts with the pro-apoptotic protein kinase MST1/2 through SARAH domains. The SARAH domain (residues 366-413) of human NORE1 was expressed in Escherichia coli, purified and crystallized using the hanging-drop vapour-diffusion method. The crystal diffracted to 2.7 angstrom resolution and belonged to space group P6(1)22, with unit-cell parameters a = b = 73.041, c = 66.092 angstrom, alpha = beta = 90, gamma = 120 degrees.
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Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
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