The Effect of Epidural Resiniferatoxin in the Neuropathic Pain Rat Model
DC Field | Value | Language |
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dc.contributor.author | Lee, Mi Geum | - |
dc.contributor.author | Huh, Billy K. | - |
dc.contributor.author | Choi, Sang Sik | - |
dc.contributor.author | Lee, Dong Kyu | - |
dc.contributor.author | Lim, Byung Gun | - |
dc.contributor.author | Lee, Mi Kyoung | - |
dc.date.accessioned | 2021-09-06T18:27:32Z | - |
dc.date.available | 2021-09-06T18:27:32Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-07 | - |
dc.identifier.issn | 1533-3159 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108126 | - |
dc.description.abstract | Background: Resiniferatoxin (RTX) is a potent synthetic agonist for transient receptor potential vanilloid subtype 1 (TRPV1), which has a selectivity for antinociception. The analgesic effect of epidural RTX in a rat model of neuropathic pain has not yet been studied. Objectives: The purpose of this study was to evaluate the analgesic effect of epidural RTX on neuropathic pain in a rat model to mechanical and thermal stimulation. The dose-related behavior changes and side effects were also studied. Study design: A randomized, experimental trial. Setting: Department of Anesthesiology and Pain Medicine, Korea University Guro Hospital Methods: A spinal nerve ligation model was prepared using male Sprague-Dawley rats (7 weeks old, weight 230-250 g). An epidural catheter was placed at the L4-L5 level. Each study group (n = 6) received a different dose of RTX: 100 ng, 500 ng, 1 mu g, 2 mu g, 4 mu g and 10 mu g. All substances were administered in 20 mu L volume doses. The control group (n = 6) received 20 mu L of normal saline. We evaluated the response to mechanical and thermal stimuli as well as the sedation score at both short-term (3 hours) and long-term (20 days) after the epidural RTX injection. Results: Prolonged analgesia to thermal stimulation was preceded by a transient dose-dependent hyperalgesia (500 ng, 1 mu g) or sedation (>= 2 mu g) during the initial 60 minutes after RTX administration. Marked sedation and hyperventilation were noted at higher doses (>= 2 mu g), while 2 out of 6 rats died with a 10 mu g dose. ED50 for epidural RTX was 265 ng (95% confidence interval 216.1-324.9 ng). The increased latency to thermal stimulation continued for 20 days at RTX >= 1 mu g. But the threshold to mechanical stimulation increased only in the acute period and returned to the baseline after 3-5 days, regardless of the administered dose. Limitations: A histological examination by electron-microscopic staining was not performed. The observation period was not very long (20 days). Conclusion: RTX has potential to be used in an epidural route for neuropathic pain in a rat model with a relatively small amount, which produces transitory improvement of mechanical hypersensitivity and prolonged thermal analgesic response. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AM SOC INTERVENTIONAL PAIN PHYSICIANS | - |
dc.subject | TACTILE ALLODYNIA | - |
dc.subject | SCIATIC-NERVE | - |
dc.subject | HYPERALGESIA | - |
dc.subject | ANALGESIA | - |
dc.subject | TRPV1 | - |
dc.subject | LIGATION | - |
dc.subject | PREVENTS | - |
dc.title | The Effect of Epidural Resiniferatoxin in the Neuropathic Pain Rat Model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Sang Sik | - |
dc.contributor.affiliatedAuthor | Lee, Dong Kyu | - |
dc.contributor.affiliatedAuthor | Lim, Byung Gun | - |
dc.contributor.affiliatedAuthor | Lee, Mi Kyoung | - |
dc.identifier.scopusid | 2-s2.0-84864459457 | - |
dc.identifier.wosid | 000306831900020 | - |
dc.identifier.bibliographicCitation | PAIN PHYSICIAN, v.15, no.4, pp.287 - 296 | - |
dc.relation.isPartOf | PAIN PHYSICIAN | - |
dc.citation.title | PAIN PHYSICIAN | - |
dc.citation.volume | 15 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 287 | - |
dc.citation.endPage | 296 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Anesthesiology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Anesthesiology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | TACTILE ALLODYNIA | - |
dc.subject.keywordPlus | SCIATIC-NERVE | - |
dc.subject.keywordPlus | HYPERALGESIA | - |
dc.subject.keywordPlus | ANALGESIA | - |
dc.subject.keywordPlus | TRPV1 | - |
dc.subject.keywordPlus | LIGATION | - |
dc.subject.keywordPlus | PREVENTS | - |
dc.subject.keywordAuthor | Epidural administration | - |
dc.subject.keywordAuthor | mechanical allodynia | - |
dc.subject.keywordAuthor | mechanical hypersensitivity | - |
dc.subject.keywordAuthor | resiniferatoxin | - |
dc.subject.keywordAuthor | sedation | - |
dc.subject.keywordAuthor | spinal nerve ligation rat model | - |
dc.subject.keywordAuthor | thermal hyperalgesia | - |
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