Comparison of immunomodulatory effects of placenta mesenchymal stem cells with bone marrow and adipose mesenchymal stem cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Jung Min | - |
dc.contributor.author | Jung, Jieun | - |
dc.contributor.author | Lee, Hyun-Jung | - |
dc.contributor.author | Jeong, Su Jin | - |
dc.contributor.author | Cho, Kyung Jin | - |
dc.contributor.author | Hwang, Seong-Gyu | - |
dc.contributor.author | Kim, Gi Jin | - |
dc.date.accessioned | 2021-09-06T18:56:24Z | - |
dc.date.available | 2021-09-06T18:56:24Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-06 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108187 | - |
dc.description.abstract | Mesenchymal stem cells (MSCs) are powerful sources for cell therapy in regenerative medicine because they can be isolated from various tissues, expanded, and induced into multiple-lineages. Of note, their immunomodulatory effects maximize the therapeutic effects of stem cells engrafted on host, making them an especially attractive choice. Recently, several varieties of placenta-derived stem cells (PDSCs) including chorionic plate-derived MSCs (CP-MSCs) have been suggested as alternative sources of stem cells. However, comparative studies of immunomodulatory effects for CP-MSCs among various MSCs are largely lacking. We examined and compared immunomodulatory function of CP-MSCs with that of BM-MSCs and AD-MSCs using co-culture system with activated T-cells derived from human umbilical cord blood (UCB) exposed to anti-CD3 and anti-CD28 which are T-cell activating monoclonal antibodies. All MSCs expressed markers of stem cells and three germ layers by RTPCR. These cells also exhibited comparable immunomodulatory effects when they were co-cultured with activated T-cells in dose-dependent manner. However, expression of HLA-ABC and HLA-G was highly positive in CP-MSCs compared to other MSCs, and higher levels of cytokines of IL-2, IL-4, IL-13, and GM-CSF were detected in dose-dependent manner in CP-MSCs. Taken together, the results of the present study suggest that while CP-MSCs, BM-MSCs, and AD-MSCs all have immunomodulatory effects, CP-MSCs may have additional advantage over the other MSCs in terms of immunomodulation. In conjunction with other previous studies, CP-MSCs are suggested to be a useful stem cell source in cell therapy. (C) 2012 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | STROMAL CELLS | - |
dc.subject | HLA-G | - |
dc.subject | PROLIFERATION | - |
dc.subject | DIFFERENTIATE | - |
dc.subject | MECHANISMS | - |
dc.subject | TOLERANCE | - |
dc.title | Comparison of immunomodulatory effects of placenta mesenchymal stem cells with bone marrow and adipose mesenchymal stem cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Kyung Jin | - |
dc.identifier.doi | 10.1016/j.intimp.2012.03.024 | - |
dc.identifier.scopusid | 2-s2.0-84860682554 | - |
dc.identifier.wosid | 000305201200013 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL IMMUNOPHARMACOLOGY, v.13, no.2, pp.219 - 224 | - |
dc.relation.isPartOf | INTERNATIONAL IMMUNOPHARMACOLOGY | - |
dc.citation.title | INTERNATIONAL IMMUNOPHARMACOLOGY | - |
dc.citation.volume | 13 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 219 | - |
dc.citation.endPage | 224 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | STROMAL CELLS | - |
dc.subject.keywordPlus | HLA-G | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | DIFFERENTIATE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | TOLERANCE | - |
dc.subject.keywordAuthor | Mesenchymal stem cells | - |
dc.subject.keywordAuthor | Immunomodulatory effects | - |
dc.subject.keywordAuthor | Placenta | - |
dc.subject.keywordAuthor | Bone marrow | - |
dc.subject.keywordAuthor | Adipose | - |
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