Comparison of immunomodulatory effects of placenta mesenchymal stem cells with bone marrow and adipose mesenchymal stem cells
- Authors
- Lee, Jung Min; Jung, Jieun; Lee, Hyun-Jung; Jeong, Su Jin; Cho, Kyung Jin; Hwang, Seong-Gyu; Kim, Gi Jin
- Issue Date
- 6월-2012
- Publisher
- ELSEVIER
- Keywords
- Mesenchymal stem cells; Immunomodulatory effects; Placenta; Bone marrow; Adipose
- Citation
- INTERNATIONAL IMMUNOPHARMACOLOGY, v.13, no.2, pp.219 - 224
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL IMMUNOPHARMACOLOGY
- Volume
- 13
- Number
- 2
- Start Page
- 219
- End Page
- 224
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/108187
- DOI
- 10.1016/j.intimp.2012.03.024
- ISSN
- 1567-5769
- Abstract
- Mesenchymal stem cells (MSCs) are powerful sources for cell therapy in regenerative medicine because they can be isolated from various tissues, expanded, and induced into multiple-lineages. Of note, their immunomodulatory effects maximize the therapeutic effects of stem cells engrafted on host, making them an especially attractive choice. Recently, several varieties of placenta-derived stem cells (PDSCs) including chorionic plate-derived MSCs (CP-MSCs) have been suggested as alternative sources of stem cells. However, comparative studies of immunomodulatory effects for CP-MSCs among various MSCs are largely lacking. We examined and compared immunomodulatory function of CP-MSCs with that of BM-MSCs and AD-MSCs using co-culture system with activated T-cells derived from human umbilical cord blood (UCB) exposed to anti-CD3 and anti-CD28 which are T-cell activating monoclonal antibodies. All MSCs expressed markers of stem cells and three germ layers by RTPCR. These cells also exhibited comparable immunomodulatory effects when they were co-cultured with activated T-cells in dose-dependent manner. However, expression of HLA-ABC and HLA-G was highly positive in CP-MSCs compared to other MSCs, and higher levels of cytokines of IL-2, IL-4, IL-13, and GM-CSF were detected in dose-dependent manner in CP-MSCs. Taken together, the results of the present study suggest that while CP-MSCs, BM-MSCs, and AD-MSCs all have immunomodulatory effects, CP-MSCs may have additional advantage over the other MSCs in terms of immunomodulation. In conjunction with other previous studies, CP-MSCs are suggested to be a useful stem cell source in cell therapy. (C) 2012 Elsevier B.V. All rights reserved.
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