Associations between gene polymorphisms and rheumatoid arthritis: a meta-analysis
- Authors
- Lee, Young Ho; Bae, Sang-Cheol; Choi, Sung Jae; Ji, Jong Dae; Song, Gwan Gyu
- Issue Date
- 6월-2012
- Publisher
- SPRINGER BASEL AG
- Keywords
- Tumor necrosis factor alpha inducible protein 3; Polymorphism; Rheumatoid arthritis; Meta-analysis
- Citation
- INFLAMMATION RESEARCH, v.61, no.6, pp.635 - 641
- Indexed
- SCIE
SCOPUS
- Journal Title
- INFLAMMATION RESEARCH
- Volume
- 61
- Number
- 6
- Start Page
- 635
- End Page
- 641
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/108210
- DOI
- 10.1007/s00011-012-0455-5
- ISSN
- 1023-3830
- Abstract
- The aim of this study was to determine whether tumor necrosis factor alpha inducible protein 3 () polymorphisms confer susceptibility to rheumatoid arthritis (RA) in ethnically different populations. The authors conducted meta-analyses on associations between the polymorphisms and RA susceptibility. A total of ten comparative studies were included in this meta-analysis, which showed an association between the two allele of rs6920220 and RA in all study subjects [odds ratio (OR) 1.216, 95% confidence interval (CI) 1.166-1.269, < 1.0 x 10(-9)]. The two allele of rs6920220 was also significantly associated with RA in Europeans only (OR 1.227, 95% CI 1.175-1.282, < 1.0 x 10(-9)). Meta-analysis revealed no association between the two allele of the rs10499194 polymorphism and RA in Europeans, but a significant association was found in Asians (OR 1.254, 95% CI 1.101-1.429, = 6.7 x 10(-4)). Furthermore, an association was found between the two allele of rs2230926 and RA in all study subjects (OR 1.390, 95% CI 1.214-2.331, = 1.9 x 10(-6)). This meta-analysis confirms that the polymorphisms are associated with RA susceptibility in different ethnic groups, namely, in Europeans for rs6920220 and in Asians for rs10499194.
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