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Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review
- Authors
- Hu, Xiaoxia; Chen, Haiying; Jin, Meishan; Wang, Xianfu; Lee, Jiyun; Xu, Weihong; Zhang, Rui; Li, Shibo; Niu, Junqi
- Issue Date
- 3-5월-2012
- Publisher
- BIOMED CENTRAL LTD
- Keywords
- Undifferentiated embryonal sarcoma of the liver (UESL); Cytogenetic anomalies; FISH; aCGH; TP53 mutation
- Citation
- MOLECULAR CYTOGENETICS, v.5
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULAR CYTOGENETICS
- Volume
- 5
- ISSN
- 1755-8166
- Abstract
- Undifferentiated embryonal sarcoma of the liver (UESL) represents a heterogeneous group of tumors derived from mesenchymal tissues. Earlier cytogenetic studies in limited cases demonstrated that UESL is associated with a recurrent translocation t(11; 19)(q11; q13.3-q13.4) or add(19)(q13.4). In this report, we present our array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH) findings, and a missense mutation of TP53 gene by DNA sequencing in a 19-year-old patient with UESL. The data were compared to laboratory findings reported by previous studies.
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