High-Performance Liquid Chromatography-Based Multivariate Analysis to Predict the Estrogenic Activity of an Epimedium koreanum Extract
DC Field | Value | Language |
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dc.contributor.author | Islam, M. Nurul | - |
dc.contributor.author | Kim, Unyong | - |
dc.contributor.author | Kim, Dong-Hyun | - |
dc.contributor.author | Dong, Mi-Sook | - |
dc.contributor.author | Yoo, Hye Hyun | - |
dc.date.accessioned | 2021-09-06T20:15:57Z | - |
dc.date.available | 2021-09-06T20:15:57Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-05 | - |
dc.identifier.issn | 0916-8451 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108504 | - |
dc.description.abstract | This study characterizes the correlation between the chemical fingerprint and estrogenic activity of an Epimedium koreanum extract. The estrogenic activity of 31 E. koreanum extract samples was evaluated by a luciferase reporter gene assay, and the samples were classified into 3 groups based on their bioactivity. A chemical fingerprint analysis was performed on each sample by high-performance liquid chromatography (HPLC), and 44 common peaks were selected from the chromatogram and used as a dataset for a pattern recognition analysis. A canonical discriminant analysis performed on this dataset determined a distinct distribution of the samples according to their estrogenic activity on the scoring plot. The classification results showed that 90.3% of the original grouped cases had been correctly classified. The total content of the 4 major extract compounds, epimedin A, epimedin B, epimedin C, and icariin, exhibited good correlation (r = 0.784) with the estrogenic activities of the respective extracts. This chromatographic fingerprint-chemometric analysis system could be useful for predicting the E. koreanum pharmacological activity and consequent biological activity-relevant quality control assessment. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | HPLC | - |
dc.subject | FLAVONOIDS | - |
dc.subject | LEAVES | - |
dc.subject | NAKAI | - |
dc.title | High-Performance Liquid Chromatography-Based Multivariate Analysis to Predict the Estrogenic Activity of an Epimedium koreanum Extract | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Dong, Mi-Sook | - |
dc.identifier.doi | 10.1271/bbb.110922 | - |
dc.identifier.scopusid | 2-s2.0-84861425397 | - |
dc.identifier.wosid | 000304640000011 | - |
dc.identifier.bibliographicCitation | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.76, no.5, pp.923 - 927 | - |
dc.relation.isPartOf | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.title | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.volume | 76 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 923 | - |
dc.citation.endPage | 927 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | HPLC | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | LEAVES | - |
dc.subject.keywordPlus | NAKAI | - |
dc.subject.keywordAuthor | Epimedium koreanum Nakai | - |
dc.subject.keywordAuthor | high-performance liquid chromatography (HPLC) | - |
dc.subject.keywordAuthor | multi-variate analysis | - |
dc.subject.keywordAuthor | estrogenic activity | - |
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