Comparison of the Adverse Events Associated with MF59-Adjuvanted and Non-Adjuvanted H1N1 Vaccines in Healthy Young Male Korean Soldiers
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, Se-Min | - |
dc.contributor.author | Kim, Hack-Lyoung | - |
dc.contributor.author | Min, Kyueng-Whan | - |
dc.contributor.author | Kim, Min | - |
dc.contributor.author | Lim, Jae-Sung | - |
dc.contributor.author | Choi, Jin-Man | - |
dc.contributor.author | Chun, Byung-Chul | - |
dc.contributor.author | Kim, Min-Jeong | - |
dc.contributor.author | Lee, Sang-Min | - |
dc.contributor.author | Kim, Seung-Young | - |
dc.contributor.author | Jeon, Han-Ho | - |
dc.date.accessioned | 2021-09-06T20:18:40Z | - |
dc.date.available | 2021-09-06T20:18:40Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-05 | - |
dc.identifier.issn | 1344-6304 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108520 | - |
dc.description.abstract | The first large-scale outbreaks of respiratory disease in the 21st century were caused by the influenza A (H1N1) virus in 2009, which affected mostly young adults. The M59 vaccine was developed to control pandemic influenza A (H1N1). However, the complications arising from the use of the non-adjuvanted and adjuvanted vaccines in young male Korean soldiers have not previously been evaluated and compared. We conducted a prospective multicenter study of 2,864 healthy male soldiers aged 19 to 25 years to evaluate the adverse events associated with both the MF59-adjuvanted and non-adjuvanted forms of the influenza A/California/2009 (H1N1) surface-antigen vaccine. In most cases, the adverse-event symptoms were mild, and the most frequent adverse events were swelling at the injection site and myalgia, which were noted in 4.8% and 10.7% of participants, respectively. Administration of the MF59-adjuvanted vaccine was associated with an increased incidence of local (crude odds ratio [cOR], 1.56; 95% confidence interval [CI], 1.11-2.29) and systemic adverse events (cOR, 1.64; 95% Cl, 1.29-2.07) after vaccination. Atopic dermatitis (adjusted OR [aOR], 2.32; 95% CI, 0.99-5.46) might be the choice risk factor for local adverse events, and adjuvant use (aOR, 1.35; 95% CI, 1.03-1.78) was a significant predictor of systemic adverse events in healthy young male Korean soldiers. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATL INST INFECTIOUS DISEASES | - |
dc.subject | INFLUENZA-VIRUS | - |
dc.subject | IMMUNOGENICITY | - |
dc.subject | SAFETY | - |
dc.subject | INFECTION | - |
dc.subject | MF59 | - |
dc.subject | DIPHTHERIA | - |
dc.subject | RESPONSES | - |
dc.subject | CHILDREN | - |
dc.subject | ANTIBODY | - |
dc.subject | TETANUS | - |
dc.title | Comparison of the Adverse Events Associated with MF59-Adjuvanted and Non-Adjuvanted H1N1 Vaccines in Healthy Young Male Korean Soldiers | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chun, Byung-Chul | - |
dc.identifier.doi | 10.7883/yoken.65.193 | - |
dc.identifier.wosid | 000304791600001 | - |
dc.identifier.bibliographicCitation | JAPANESE JOURNAL OF INFECTIOUS DISEASES, v.65, no.3, pp.193 - 197 | - |
dc.relation.isPartOf | JAPANESE JOURNAL OF INFECTIOUS DISEASES | - |
dc.citation.title | JAPANESE JOURNAL OF INFECTIOUS DISEASES | - |
dc.citation.volume | 65 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 193 | - |
dc.citation.endPage | 197 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.subject.keywordPlus | INFLUENZA-VIRUS | - |
dc.subject.keywordPlus | IMMUNOGENICITY | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | MF59 | - |
dc.subject.keywordPlus | DIPHTHERIA | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | ANTIBODY | - |
dc.subject.keywordPlus | TETANUS | - |
dc.subject.keywordAuthor | INFLUENZA-VIRUS | - |
dc.subject.keywordAuthor | IMMUNOGENICITY | - |
dc.subject.keywordAuthor | SAFETY | - |
dc.subject.keywordAuthor | INFECTION | - |
dc.subject.keywordAuthor | DIPHTHERIA | - |
dc.subject.keywordAuthor | RESPONSES | - |
dc.subject.keywordAuthor | ANTIBODY | - |
dc.subject.keywordAuthor | CHILDREN | - |
dc.subject.keywordAuthor | TETANUS | - |
dc.subject.keywordAuthor | MF59 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.