Comparison of the Adverse Events Associated with MF59-Adjuvanted and Non-Adjuvanted H1N1 Vaccines in Healthy Young Male Korean Soldiers
- Authors
- Hwang, Se-Min; Kim, Hack-Lyoung; Min, Kyueng-Whan; Kim, Min; Lim, Jae-Sung; Choi, Jin-Man; Chun, Byung-Chul; Kim, Min-Jeong; Lee, Sang-Min; Kim, Seung-Young; Jeon, Han-Ho
- Issue Date
- 5월-2012
- Publisher
- NATL INST INFECTIOUS DISEASES
- Keywords
- INFLUENZA-VIRUS; IMMUNOGENICITY; SAFETY; INFECTION; DIPHTHERIA; RESPONSES; ANTIBODY; CHILDREN; TETANUS; MF59
- Citation
- JAPANESE JOURNAL OF INFECTIOUS DISEASES, v.65, no.3, pp.193 - 197
- Indexed
- SCIE
SCOPUS
- Journal Title
- JAPANESE JOURNAL OF INFECTIOUS DISEASES
- Volume
- 65
- Number
- 3
- Start Page
- 193
- End Page
- 197
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/108520
- DOI
- 10.7883/yoken.65.193
- ISSN
- 1344-6304
- Abstract
- The first large-scale outbreaks of respiratory disease in the 21st century were caused by the influenza A (H1N1) virus in 2009, which affected mostly young adults. The M59 vaccine was developed to control pandemic influenza A (H1N1). However, the complications arising from the use of the non-adjuvanted and adjuvanted vaccines in young male Korean soldiers have not previously been evaluated and compared. We conducted a prospective multicenter study of 2,864 healthy male soldiers aged 19 to 25 years to evaluate the adverse events associated with both the MF59-adjuvanted and non-adjuvanted forms of the influenza A/California/2009 (H1N1) surface-antigen vaccine. In most cases, the adverse-event symptoms were mild, and the most frequent adverse events were swelling at the injection site and myalgia, which were noted in 4.8% and 10.7% of participants, respectively. Administration of the MF59-adjuvanted vaccine was associated with an increased incidence of local (crude odds ratio [cOR], 1.56; 95% confidence interval [CI], 1.11-2.29) and systemic adverse events (cOR, 1.64; 95% Cl, 1.29-2.07) after vaccination. Atopic dermatitis (adjusted OR [aOR], 2.32; 95% CI, 0.99-5.46) might be the choice risk factor for local adverse events, and adjuvant use (aOR, 1.35; 95% CI, 1.03-1.78) was a significant predictor of systemic adverse events in healthy young male Korean soldiers.
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