Rufinamide as an adjuvant treatment in children with Lennox-Gastaut syndrome
- Authors
- Kim, Shin Hye; Eun, So-Hee; Kang, Hoon-Chul; Kwon, Eun Ji; Byeon, Jung Hye; Lee, Young-Mock; Lee, Joon Soo; Eun, Baik-Lin; Kim, Heung Dong
- Issue Date
- May-2012
- Publisher
- W B SAUNDERS CO LTD
- Keywords
- Rufinamide; Lennox-Gastaut syndrome; Child
- Citation
- SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, v.21, no.4, pp.288 - 291
- Indexed
- SCIE
SCOPUS
- Journal Title
- SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
- Volume
- 21
- Number
- 4
- Start Page
- 288
- End Page
- 291
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/108561
- DOI
- 10.1016/j.seizure.2012.02.006
- ISSN
- 1059-1311
- Abstract
- Purpose: To evaluate the efficacy of rufinamide as an add-on treatment in children and adolescents with Lennox-Gastaut syndrome (LGS). Methods: The study was an open-label, observational clinical trial of rufinamide as an add-on treatment in intractable LGS patients. This intent-to-treat trial included 4 weeks of scheduled titrated doses and a 12-week maintenance phase with a target dose of 20-40 mg/kg rufinamide, adjusted according to its effectiveness and tolerability after a baseline period of 4 weeks. The primary outcome was measured by the seizure-reduction rate according to individual seizure type over the 12-week maintenance period. Results: One hundred and twenty-eight patients with LGS who were determined to be unresponsive to one or more antiepileptic drugs or dietary therapy were enrolled. Of the 128 patients enrolled, 112 (87.5%) completed the study. After add-on rufinamide treatment, 46 patients (35.9%) achieved a more than 50% reduction in seizure frequency and 10(7.8%) patients became seizure-free. When we identified those who responded with an at least 50% reduction in seizure frequency, 39.4% of the responders reported reductions in convulsive seizures, 36.4% in drop attacks, 33.3% in myoclonic seizures, and 20.0% in epileptic spasms. Overall, 32.8% of patients reported adverse effects, which were mostly mild and transient in nature. The most common adverse effects were fatigue (15 patients, 11.7%) and poor appetite (9 patients, 7.0%). Twenty-one (16.4%) patients experienced an increased seizure frequency. Conclusions: Rufinamide appears to be a safe and effective adjuvant treatment for many cases of intractable LGS. (C) 2012 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
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