Polyhydroxylated Macrolides from Seimatosporium discosioides and Their Effects on the Activation of Peroxisome Proliferator-Activated Receptor Gamma
- Authors
- Nguyen Tuan Hiep; Choi, Yun-Hyeok; Kim, Nahyun; Hong, Seong Su; Hong, Seung-Beom; Hwang, Bang Yeon; Lee, Hak-Ju; Lee, Sung-Joon; Jang, Dae Sik; Lee, Dongho
- Issue Date
- Apr-2012
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.75, no.4, pp.784 - 788
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 75
- Number
- 4
- Start Page
- 784
- End Page
- 788
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/108777
- DOI
- 10.1021/np200955z
- ISSN
- 0163-3864
- Abstract
- Two new polyhydroxylated macrolides, seimatopolides A (1) and B (2), were isolated from an EtOAc extract of Seimatosporium discosioides culture medium. The structures of the new compounds were established on the basis of spectroscopic analysis, including 1D and 2D NMR, and their absolute configurations were determined using the modified Mosher's method. Seimatopolides A (1) and B (2) activated peroxisome proliferator-activated receptor (PPAR)-gamma with EC50 values of 1.15 and 11.05 mu M, respectively. The expression of PPAR-gamma target genes in HepG2 hepatocytes was significantly altered; in particular, expression of the gluconeogenic genes glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) was reduced upon stimulation with 1, supporting the proposal that compound 1 is both a PPAR-gamma agonist and a possible therapeutic candidate for treatment of diabetes.
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