The relationship between interleukin-6, tumor necrosis factor-alpha, and fatigue in terminally ill cancer patients
DC Field | Value | Language |
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dc.contributor.author | Kwak, Sang Mi | - |
dc.contributor.author | Choi, Youn Seon | - |
dc.contributor.author | Yoon, Ho Min | - |
dc.contributor.author | Kim, Dae Gyun | - |
dc.contributor.author | Song, Seung Hun | - |
dc.contributor.author | Lee, Young Jae | - |
dc.contributor.author | Yeom, Chang Hwan | - |
dc.contributor.author | Koh, Su Jin | - |
dc.contributor.author | Park, Jeanno | - |
dc.contributor.author | Lee, Myung Ah | - |
dc.contributor.author | Suh, Sang-Yeon | - |
dc.date.accessioned | 2021-09-06T21:38:29Z | - |
dc.date.available | 2021-09-06T21:38:29Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-04 | - |
dc.identifier.issn | 0269-2163 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108793 | - |
dc.description.abstract | Although many cancer patients receiving palliative care experience distressing levels of fatigue, no well-designed studies have investigated contributing factors in Korean patients. We conducted a cross-sectional study using the Brief Fatigue Inventory-K (BFI-K) to measure fatigue while assessing a variety of possible correlates. Ninety patients with incurable cancer in the terminal stage (median survival: 27 days) participated in a structured interview and questionnaire related to their medical conditions and underwent blood sampling for laboratory data and cytokines, including interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha. Body mass index, dyspnea, the Eastern Cooperative Oncology Group performance status, and levels of albumin, blood urea nitrogen (BUN), total bilirubin, and C-reactive protein were significantly associated with fatigue. However, levels of the two proinflammatory cytokines, IL-6 and TNF-alpha, were not significantly correlated with the BFI-K score. In stepwise multiple linear regression, fatigue was related to elevated BUN (beta = 0.376, p = 0.002), severe pain intensity (beta = 0.349, p = 0.004), and impaired performance status (beta = 0.268, p = 0.027), but not related to levels of inflammatory cytokines. In conclusion, the diagnostic work-up and therapeutic plan for patients with cancer-related fatigue should include an evaluation of laboratory parameters, pain severity, and physical performance. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.subject | QUALITY-OF-LIFE | - |
dc.subject | BREAST-CANCER | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | MONOCLONAL-ANTIBODY | - |
dc.subject | COMMUNITY ONCOLOGY | - |
dc.subject | EPOETIN ALPHA | - |
dc.subject | LUNG-CANCER | - |
dc.subject | CYTOKINES | - |
dc.subject | SURVIVORS | - |
dc.subject | INVENTORY | - |
dc.title | The relationship between interleukin-6, tumor necrosis factor-alpha, and fatigue in terminally ill cancer patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Youn Seon | - |
dc.identifier.doi | 10.1177/0269216311406991 | - |
dc.identifier.scopusid | 2-s2.0-84863366905 | - |
dc.identifier.wosid | 000301799800010 | - |
dc.identifier.bibliographicCitation | PALLIATIVE MEDICINE, v.26, no.3, pp.275 - 282 | - |
dc.relation.isPartOf | PALLIATIVE MEDICINE | - |
dc.citation.title | PALLIATIVE MEDICINE | - |
dc.citation.volume | 26 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 275 | - |
dc.citation.endPage | 282 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Health Care Sciences & Services | - |
dc.relation.journalResearchArea | Public, Environmental & Occupational Health | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Health Care Sciences & Services | - |
dc.relation.journalWebOfScienceCategory | Public, Environmental & Occupational Health | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | QUALITY-OF-LIFE | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | MONOCLONAL-ANTIBODY | - |
dc.subject.keywordPlus | COMMUNITY ONCOLOGY | - |
dc.subject.keywordPlus | EPOETIN ALPHA | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | SURVIVORS | - |
dc.subject.keywordPlus | INVENTORY | - |
dc.subject.keywordAuthor | Blood urea nitrogen | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordAuthor | fatigue | - |
dc.subject.keywordAuthor | pain | - |
dc.subject.keywordAuthor | physical performance | - |
dc.subject.keywordAuthor | terminal cancer | - |
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