The relationship between interleukin-6, tumor necrosis factor-alpha, and fatigue in terminally ill cancer patients
- Authors
- Kwak, Sang Mi; Choi, Youn Seon; Yoon, Ho Min; Kim, Dae Gyun; Song, Seung Hun; Lee, Young Jae; Yeom, Chang Hwan; Koh, Su Jin; Park, Jeanno; Lee, Myung Ah; Suh, Sang-Yeon
- Issue Date
- 4월-2012
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- Blood urea nitrogen; cytokine; fatigue; pain; physical performance; terminal cancer
- Citation
- PALLIATIVE MEDICINE, v.26, no.3, pp.275 - 282
- Indexed
- SCIE
SCOPUS
- Journal Title
- PALLIATIVE MEDICINE
- Volume
- 26
- Number
- 3
- Start Page
- 275
- End Page
- 282
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/108793
- DOI
- 10.1177/0269216311406991
- ISSN
- 0269-2163
- Abstract
- Although many cancer patients receiving palliative care experience distressing levels of fatigue, no well-designed studies have investigated contributing factors in Korean patients. We conducted a cross-sectional study using the Brief Fatigue Inventory-K (BFI-K) to measure fatigue while assessing a variety of possible correlates. Ninety patients with incurable cancer in the terminal stage (median survival: 27 days) participated in a structured interview and questionnaire related to their medical conditions and underwent blood sampling for laboratory data and cytokines, including interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha. Body mass index, dyspnea, the Eastern Cooperative Oncology Group performance status, and levels of albumin, blood urea nitrogen (BUN), total bilirubin, and C-reactive protein were significantly associated with fatigue. However, levels of the two proinflammatory cytokines, IL-6 and TNF-alpha, were not significantly correlated with the BFI-K score. In stepwise multiple linear regression, fatigue was related to elevated BUN (beta = 0.376, p = 0.002), severe pain intensity (beta = 0.349, p = 0.004), and impaired performance status (beta = 0.268, p = 0.027), but not related to levels of inflammatory cytokines. In conclusion, the diagnostic work-up and therapeutic plan for patients with cancer-related fatigue should include an evaluation of laboratory parameters, pain severity, and physical performance.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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