New Method of Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) for Rat Brain Research
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Keun-Yeong | - |
dc.contributor.author | Lee, Chulhyun | - |
dc.contributor.author | Cho, Jee-Hyun | - |
dc.contributor.author | Kang, Ji-Hyuk | - |
dc.contributor.author | Na, Heung-Sik | - |
dc.date.accessioned | 2021-09-06T21:44:48Z | - |
dc.date.available | 2021-09-06T21:44:48Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-04 | - |
dc.identifier.issn | 1341-1357 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108827 | - |
dc.description.abstract | Manganese (Mn2+)-enhanced MRI (MEMRI) is known to provide insight into functional and anatomical biology. However, this method, which uses Mn2+ as a MRI-detectable contrast agent, has drawbacks such as the toxicity to cells beyond a certain level of Mn2+. In this study, we attempt to determine a new method of ICV administration, the optimal concentration of administered Mn2+ and the optimal MEMRI acquisition time following administration. Male Sprague-Dawley rats were used in the following experimental sessions: (1) intracerebroventricular (ICV) cannula implantation in the region of the cisterna magna, (2) serial dilution of MnCl2 (20-80 mM), (3) ICV administration of MnCl2 through the cannula, and (4) T-1-weighted MRI measurements. We confirmed that cannula implantation in the region of the cisterna magna was a new ICV injection method for the administration of a contrast agent. The optimal concentration for MEMRI was 20/50 mM/mu l of MnCl2. The MEMRI data acquired at different time points indicate that most signal enhancement is maintained during 14-48 h after contrast agent injection, and 24 h was the optimal time to acquire images of the rat brain. The present study offers optimized parameters for contrast agent injection that would be a good basis for studies using MEMRI to research the rat brain. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | INT PRESS EDITING CENTRE INC | - |
dc.subject | IN-VIVO | - |
dc.subject | 3D MRI | - |
dc.subject | MOUSE-BRAIN | - |
dc.subject | MNCL2 | - |
dc.subject | MICE | - |
dc.subject | NEUROTOXICITY | - |
dc.subject | INJECTION | - |
dc.subject | TOXICITY | - |
dc.subject | CONTRAST | - |
dc.subject | SYSTEM | - |
dc.title | New Method of Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) for Rat Brain Research | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Na, Heung-Sik | - |
dc.identifier.doi | 10.1538/expanim.61.157 | - |
dc.identifier.scopusid | 2-s2.0-84861468497 | - |
dc.identifier.wosid | 000303036600010 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL ANIMALS, v.61, no.2, pp.157 - 164 | - |
dc.relation.isPartOf | EXPERIMENTAL ANIMALS | - |
dc.citation.title | EXPERIMENTAL ANIMALS | - |
dc.citation.volume | 61 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 157 | - |
dc.citation.endPage | 164 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Veterinary Sciences | - |
dc.relation.journalResearchArea | Zoology | - |
dc.relation.journalWebOfScienceCategory | Veterinary Sciences | - |
dc.relation.journalWebOfScienceCategory | Zoology | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | 3D MRI | - |
dc.subject.keywordPlus | MOUSE-BRAIN | - |
dc.subject.keywordPlus | MNCL2 | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | NEUROTOXICITY | - |
dc.subject.keywordPlus | INJECTION | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | CONTRAST | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordAuthor | cannula implantation | - |
dc.subject.keywordAuthor | intracerebroventricular injection | - |
dc.subject.keywordAuthor | manganese-enhanced MRI | - |
dc.subject.keywordAuthor | Mn2+ | - |
dc.subject.keywordAuthor | rat brain | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.