Moracenin D from Mori Cortex Radicis Protects SH-SY5Y Cells against Dopamine-induced Cell Death by Regulating Nurr1 and alpha-Synuclein Expression
- Authors
- Ham, Ahrom; Lee, Hak Ju; Hong, Seong Su; Lee, Dongho; Mar, Woongchon
- Issue Date
- Apr-2012
- Publisher
- WILEY-BLACKWELL
- Keywords
- Mori Cortex radicis; moracenin D; dopamine; Nurr1; alpha-synuclein
- Citation
- PHYTOTHERAPY RESEARCH, v.26, no.4, pp.620 - 624
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHYTOTHERAPY RESEARCH
- Volume
- 26
- Number
- 4
- Start Page
- 620
- End Page
- 624
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/108891
- DOI
- 10.1002/ptr.3592
- ISSN
- 0951-418X
- Abstract
- In our efforts to find neuroprotective materials of plant origin, several compounds were isolated from Mori Cortex Radicis. The protective effect against dopamine-induced cell death was examined, and the subsequent effects on the levels of expression of Parkinson's disease-associated nurr1 and a-synuclein were evaluated in a dopamine-induced system. Five compounds were isolated and moracenin D protected cell death against dopamine-induction in human neuroblastoma SH-SY5Y cells. The effects of moracenin D on the levels of mRNA and protein expression of nurr1 and a-synuclein were subsequently examined using reverse transcription-polymerase chain reaction (RT-PCR) and western blot analysis. Treatment with moracenin D resulted in an up-regulation of nurr1 mRNA levels and a down-regulation of a-synuclein mRNA levels. Additionally, the a-synuclein protein expression was decreased in accordance with an increase in nurr1 protein expression. These results demonstrate that the protective effects of moracenin D were presumably due to the correlative effects on the up-regulation of nurr1 and down-regulation of a-synuclein expressions against dopamine induction. Therefore, moracenin D can be considered as a candidate for therapy for Parkinson's disease. Copyright (C) 2011 John Wiley & Sons, Ltd.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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