Low-dose Radiation Induces Drosophila Innate Immunity through Toll Pathway Activation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seong, Ki Moon | - |
dc.contributor.author | Kim, Cha Soon | - |
dc.contributor.author | Lee, Byung-Sub | - |
dc.contributor.author | Nam, Seon Young | - |
dc.contributor.author | Yang, Kwang Hee | - |
dc.contributor.author | Kim, Ji-Young | - |
dc.contributor.author | Park, Joong-Jean | - |
dc.contributor.author | Min, Kyung-Jin | - |
dc.contributor.author | Jin, Young-Woo | - |
dc.date.accessioned | 2021-09-06T22:35:07Z | - |
dc.date.available | 2021-09-06T22:35:07Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-03 | - |
dc.identifier.issn | 0449-3060 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108998 | - |
dc.description.abstract | Numerous studies report that exposing certain organisms to low-dose radiation induces beneficial effects on lifespan, tumorigenesis, and immunity. By analyzing survival after bacterial infection and antimicrobial peptide gene expression in irradiated flies, we demonstrate that low-dose irradiation of Drosophila enhances innate immunity. Low-dose irradiation of flies significantly increased resistance against gram-positive and gram-negative bacterial infections, as well as expression of several antimicrobial peptide genes. Additionally, low-dose irradiation also resulted in a specific increase in expression of key proteins of the Toll signaling pathway and phosphorylated forms of p38 and JNK. These results indicate that innate immunity is activated after low-dose irradiation through Toll signaling pathway in Drosophila. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject | HOST-DEFENSE | - |
dc.subject | JNK | - |
dc.subject | MELANOGASTER | - |
dc.subject | RESPONSES | - |
dc.subject | HORMESIS | - |
dc.subject | LONGEVITY | - |
dc.title | Low-dose Radiation Induces Drosophila Innate Immunity through Toll Pathway Activation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Joong-Jean | - |
dc.identifier.doi | 10.1269/jrr.11170 | - |
dc.identifier.scopusid | 2-s2.0-84863488204 | - |
dc.identifier.wosid | 000307196400011 | - |
dc.identifier.bibliographicCitation | JOURNAL OF RADIATION RESEARCH, v.53, no.2, pp.242 - 249 | - |
dc.relation.isPartOf | JOURNAL OF RADIATION RESEARCH | - |
dc.citation.title | JOURNAL OF RADIATION RESEARCH | - |
dc.citation.volume | 53 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 242 | - |
dc.citation.endPage | 249 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | HOST-DEFENSE | - |
dc.subject.keywordPlus | JNK | - |
dc.subject.keywordPlus | MELANOGASTER | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | HORMESIS | - |
dc.subject.keywordPlus | LONGEVITY | - |
dc.subject.keywordAuthor | Low-dose radiation | - |
dc.subject.keywordAuthor | Innate immunity | - |
dc.subject.keywordAuthor | Toll | - |
dc.subject.keywordAuthor | JNK | - |
dc.subject.keywordAuthor | Drosophila | - |
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