Low-dose Radiation Induces Drosophila Innate Immunity through Toll Pathway Activation
- Authors
- Seong, Ki Moon; Kim, Cha Soon; Lee, Byung-Sub; Nam, Seon Young; Yang, Kwang Hee; Kim, Ji-Young; Park, Joong-Jean; Min, Kyung-Jin; Jin, Young-Woo
- Issue Date
- 3월-2012
- Publisher
- OXFORD UNIV PRESS
- Keywords
- Low-dose radiation; Innate immunity; Toll; JNK; Drosophila
- Citation
- JOURNAL OF RADIATION RESEARCH, v.53, no.2, pp.242 - 249
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF RADIATION RESEARCH
- Volume
- 53
- Number
- 2
- Start Page
- 242
- End Page
- 249
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/108998
- DOI
- 10.1269/jrr.11170
- ISSN
- 0449-3060
- Abstract
- Numerous studies report that exposing certain organisms to low-dose radiation induces beneficial effects on lifespan, tumorigenesis, and immunity. By analyzing survival after bacterial infection and antimicrobial peptide gene expression in irradiated flies, we demonstrate that low-dose irradiation of Drosophila enhances innate immunity. Low-dose irradiation of flies significantly increased resistance against gram-positive and gram-negative bacterial infections, as well as expression of several antimicrobial peptide genes. Additionally, low-dose irradiation also resulted in a specific increase in expression of key proteins of the Toll signaling pathway and phosphorylated forms of p38 and JNK. These results indicate that innate immunity is activated after low-dose irradiation through Toll signaling pathway in Drosophila.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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