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Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages
- Authors
- Hwang, Ji Sang; Lee, Seon A.; Hong, Seong Su; Han, Xiang Hua; Lee, Chul; Lee, Dongho; Lee, Chong-Kil; Hong, Jin Tae; Kim, Youngsoo; Lee, Mi Kyeong; Hwang, Bang Yeon
- Issue Date
- 1-Jan-2012
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Nardostachys chinensis; Valerianaceae; Sesquiterpenoid; Nitric oxide inhibitor
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.22, no.1, pp.706 - 708
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 22
- Number
- 1
- Start Page
- 706
- End Page
- 708
- ISSN
- 0960-894X
- Abstract
- The activity-guided fractionation of the MeOH extract of the rhizomes and roots of Nardostachys chinensis led to the isolation of two new sesquiterpenoids, narchinol B (8) and narchinol C (9), along with 10 known compounds, ursolic acid (1), nardosinone (2), pinoresinol (3), desoxo-narchinol A (4), kanshone B (5), epoxyconiferyl alcohol (6), debilon (7), 4 alpha,5-dimethyl-1,3-dioxo-1,2,3,4,4 alpha,5,6,7-octahydronaphthalene (10), p-coumaric acid (11), and isoferulic acid (12). Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. Among the isolates, compounds 2, 4, 5, 8 and 9 showed inhibitory activity against LPS-induced NO production with IC50 values of 4.6-21.6 mu M. (C) 2011 Elsevier Ltd. All rights reserved.
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Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology