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The relationship between twin births and maternal risk of breast cancer: a meta-analysis

Authors
Kim, Hye SookWoo, Ok HeePark, Kyong HwaWoo, Sang UkYang, Dae SikKim, Ae-ReeLee, Eun SookLee, Jae-BokKim, Yeul HongKim, Jun SukSeo, Jae Hong
Issue Date
1월-2012
Publisher
SPRINGER
Keywords
Twin births; Breast cancer; Meta-analysis
Citation
BREAST CANCER RESEARCH AND TREATMENT, v.131, no.2, pp.671 - 677
Indexed
SCIE
SCOPUS
Journal Title
BREAST CANCER RESEARCH AND TREATMENT
Volume
131
Number
2
Start Page
671
End Page
677
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/109165
DOI
10.1007/s10549-011-1779-5
ISSN
0167-6806
Abstract
Women who undergo a greater number of menstrual cycles may be at increased risk of breast cancer, possibly due to cumulative exposure to ovarian hormones. Pregnancy reduces the lifetime number of menstrual cycles and also influences the levels of ovarian hormones. Twin pregnancies differ from singleton pregnancies in both hormone levels and perinatal changes. To date, a meta-analysis on the effects of twin birth on the risk of maternal breast cancer has not been conducted. Among 17 relevant publications identified in a systematic search, some suggest that twin births may be associated with lower breast cancer risk but others do not; therefore, the results are inconclusive. Although our pooled results of all 17 published studies did not show a reduced maternal risk of breast cancer for twin births (HR 0.94; 95% CI = 0.87-1.02; P = 0.127), a trend toward reduced maternal risk of breast cancer was identified in a subgroup analysis of cohort studies (HR 0.91; 95% CI = 0.83-1.01; P = 0.068). The results of this meta-analysis suggest that twin pregnancy does not significantly decrease the maternal risk of breast cancer.
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