Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Transcranial Focused Ultrasound to the Thalamus Is Associated with Reduced Extracellular GABA Levels in Rats

Authors
Yang, Po SongKim, HyungminLee, WonhyeBohlke, MarkPark, ShinsukMaher, Timothy J.Yoo, Seung-Schik
Issue Date
2012
Publisher
KARGER
Keywords
Brain stimulation; Focused ultrasound; GABA; Glutamate; Neuromodulation; Neurotransmitters; Thalamus
Citation
NEUROPSYCHOBIOLOGY, v.65, no.3, pp.153 - 160
Indexed
SCIE
SCOPUS
Journal Title
NEUROPSYCHOBIOLOGY
Volume
65
Number
3
Start Page
153
End Page
160
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/109271
DOI
10.1159/000336001
ISSN
0302-282X
Abstract
Objective: Transcranial focused ultrasound (FUS), with its ability to non-invasively modulate the excitability of region specific brain areas, is gaining attention as a potential neurotherapeutic modality. The aim of this study was to examine whether or not FUS administered to the brain could alter the extracellular levels of glutamate and gamma-aminobutyric acid (GABA), which are representative excitatory and inhibitory amino acid neurotransmitters, respectively. Methods: FUS, delivered in the form of a train of pulses, was applied to the thalamus of Sprague-Dawley rats transcranially. Glutamate and GABA were directly sampled from the frontal lobe of the rat brain via a direct microdialysis technique before, during, and after the sonication. The dialysate concentrations were determined by high-performance liquid chromatography. Results: The individual levels of the neurotransmitters sampled were normalized to the baseline level for each rat. In terms of the changes in extracellular glutamate levels, there was no difference between the FUS-treated group and the unsonicated control group. However, extracellular GABA levels started to decrease upon sonication and remained reduced (approximately 20% below baseline; repeated-measures ANOVA, p < 0.05, adjusted for multiple comparisons) compared to the control group. Conclusion: The ability to modulate region-specific brain activity, along with the present evidence of the ability to modulate neurotransmission, demonstrates the potential utility of FUS as a completely new non-invasive therapeutic modality. Copyright (C) 2012 S. Karger AG, Basel
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Engineering > Department of Mechanical Engineering > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher PARK, SHIN SUK photo

PARK, SHIN SUK
공과대학 (기계공학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE