Effects of Yeast Hydrolysate on Hepatic Lipid Metabolism in High-Fat-Diet-Induced Obese Mice: Yeast Hydrolysate Suppresses Body Fat Accumulation by Attenuating Fatty Acid Synthesis
DC Field | Value | Language |
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dc.contributor.author | Jung, Eun Young | - |
dc.contributor.author | Hong, Yang-Hee | - |
dc.contributor.author | Kim, Jae Hwan | - |
dc.contributor.author | Park, Yooheon | - |
dc.contributor.author | Bae, Song Hwan | - |
dc.contributor.author | Chang, Un Jae | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.date.accessioned | 2021-09-07T00:10:26Z | - |
dc.date.available | 2021-09-07T00:10:26Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0250-6807 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/109414 | - |
dc.description.abstract | Aims: We observed whether the anti-obesity activity of yeast hydrolysate (YH) was due to the alteration of lipid-regulating enzyme activities. Methods: Male ICR mice were divided into four groups: a normal diet group (ND; 4.2% fat), a high-fat diet group (HF; 27.7% fat), an HF group treated orally with 0.5% or 1% YH in the drinking water (HF+YH0.5; 27.7% fat and HF+YH1; 27.7% fat). Results: After 5 weeks, the YH groups (HF+YH0.5 = 3.92 +/- 0.17 g/100 g BW and HF+YH1 = 3.76 +/- 0.13 g/100 g BW) had significantly lower levels of epididymal fats compared to the HF group (4.91 +/- 0.29 g/100 g BW; p<0.05). YH supplementation produced a decrease in serum triglycerides and low-density lipoprotein cholesterol concentrations and body weight gain, and produced a dose-dependent significant increase in serum ghrelin compared with the HF group (p<0.05). Hepatic glucose-6-phosphate dehydrogenase (G6PD) activity was inhibited by YH supplementation compared with the HF group, and mice treated orally with 1% YH exhibited a significant decrease in hepatic malic enzyme (ME) activity compared to obese mice treated with the vehicle (HF = 10.44 +/- 2.74 nmol/min/mg protein vs. HF+YH1 = 6.68 +/- 2.23 nmol/min/mg protein; p<0.05). Conclusions: YH supplementation suppressed body fat accumulation by attenuating fatty acid synthesis through the downregulation of hepatic G6PD and ME activities. Copyright (C) 2012 S. Karger AG, Basel | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.subject | VISCERAL OBESITY | - |
dc.subject | IMMUNOREACTIVITY | - |
dc.subject | SUBSTRATE | - |
dc.subject | LIVER | - |
dc.title | Effects of Yeast Hydrolysate on Hepatic Lipid Metabolism in High-Fat-Diet-Induced Obese Mice: Yeast Hydrolysate Suppresses Body Fat Accumulation by Attenuating Fatty Acid Synthesis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Yooheon | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.1159/000338441 | - |
dc.identifier.scopusid | 2-s2.0-84864809833 | - |
dc.identifier.wosid | 000310099600001 | - |
dc.identifier.bibliographicCitation | ANNALS OF NUTRITION AND METABOLISM, v.61, no.2, pp.89 - 94 | - |
dc.relation.isPartOf | ANNALS OF NUTRITION AND METABOLISM | - |
dc.citation.title | ANNALS OF NUTRITION AND METABOLISM | - |
dc.citation.volume | 61 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 89 | - |
dc.citation.endPage | 94 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | VISCERAL OBESITY | - |
dc.subject.keywordPlus | IMMUNOREACTIVITY | - |
dc.subject.keywordPlus | SUBSTRATE | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordAuthor | Yeast hydrolysate | - |
dc.subject.keywordAuthor | Ghrelin | - |
dc.subject.keywordAuthor | Epididymal fat | - |
dc.subject.keywordAuthor | Glucose-6-phosphate dehydrogenase | - |
dc.subject.keywordAuthor | Malic enzyme | - |
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