pH-responsive water soluble smart vesicles containing a bis(styryl)benzene derivative for two-photon microscopy imaging
DC Field | Value | Language |
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dc.contributor.author | Nag, Okhil Kumar | - |
dc.contributor.author | Lim, Chang Su | - |
dc.contributor.author | Bao Lam Nguyen | - |
dc.contributor.author | Kim, Boram | - |
dc.contributor.author | Jang, Jihye | - |
dc.contributor.author | Han, Ji Hee | - |
dc.contributor.author | Cho, Bong Rae | - |
dc.contributor.author | Woo, Han Young | - |
dc.date.accessioned | 2021-09-07T00:12:53Z | - |
dc.date.available | 2021-09-07T00:12:53Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0959-9428 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/109429 | - |
dc.description.abstract | We report self-assembled polymeric nanovesicles composed of 1,4-bis{4'-[N,N-bis(6 ''-trimethylammoniumhexyl)amino]styryl}benzene tetrabromide (C1), poly[(ethylene oxide)-block-(sodium 2-acrylamido-2-methyl-1-propane sulfonate)] (E-m-A(n)), and hexadecyltrimethylammonium bromide (C-16). Transmission electron microscopy (TEM) micrographs confirm the vesicular bilayer structures and atomic force microscopy (AFM) images show that the C1/E-m-A(n)/C-16 complexes form spherical nanostructures with a particle size ranging from 40 to 80 nm. The encapsulation of C1 inside the nanovesicles enhances similar to 2-fold the fluorescence quantum yield (eta) and two-photon action cross-section (eta delta, where delta is the two-photon absorption cross-section), and allows internalization into the cells, as revealed by the bright two-photon microscopy (TPM) images of human cervical epithelioid carcinoma (HeLa) cells labeled with the nanovesicles. Moreover, nanovesicles containing a chemotherapeutic drug and a neutral molecule can also be prepared. Furthermore, the C1/vesicular complex is disassembled under acidic conditions, highlighting its potential as a pH-responsive smart nanocarrier for the intracellular drug delivery. These results suggest a new possibility of using nanovesicles as efficient two-photon probes for TPM imaging and possibly as nanocarriers for intracellular drug delivery. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | AGGREGATION-ENHANCED FLUORESCENCE | - |
dc.subject | MODIFIED SILICA NANOPARTICLES | - |
dc.subject | ABSORPTION | - |
dc.subject | EXCITATION | - |
dc.subject | COMPLEXES | - |
dc.subject | POLYMER | - |
dc.subject | SULFATE | - |
dc.subject | SURFACTANT | - |
dc.subject | PROBES | - |
dc.subject | CHROMOPHORES | - |
dc.title | pH-responsive water soluble smart vesicles containing a bis(styryl)benzene derivative for two-photon microscopy imaging | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Bong Rae | - |
dc.identifier.doi | 10.1039/c1jm14693a | - |
dc.identifier.scopusid | 2-s2.0-84862917700 | - |
dc.identifier.wosid | 000298970700036 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MATERIALS CHEMISTRY, v.22, no.5, pp.1977 - 1984 | - |
dc.relation.isPartOf | JOURNAL OF MATERIALS CHEMISTRY | - |
dc.citation.title | JOURNAL OF MATERIALS CHEMISTRY | - |
dc.citation.volume | 22 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1977 | - |
dc.citation.endPage | 1984 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | AGGREGATION-ENHANCED FLUORESCENCE | - |
dc.subject.keywordPlus | MODIFIED SILICA NANOPARTICLES | - |
dc.subject.keywordPlus | ABSORPTION | - |
dc.subject.keywordPlus | EXCITATION | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | POLYMER | - |
dc.subject.keywordPlus | SULFATE | - |
dc.subject.keywordPlus | SURFACTANT | - |
dc.subject.keywordPlus | PROBES | - |
dc.subject.keywordPlus | CHROMOPHORES | - |
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