pH-responsive water soluble smart vesicles containing a bis(styryl)benzene derivative for two-photon microscopy imaging
- Authors
- Nag, Okhil Kumar; Lim, Chang Su; Bao Lam Nguyen; Kim, Boram; Jang, Jihye; Han, Ji Hee; Cho, Bong Rae; Woo, Han Young
- Issue Date
- 2012
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- JOURNAL OF MATERIALS CHEMISTRY, v.22, no.5, pp.1977 - 1984
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF MATERIALS CHEMISTRY
- Volume
- 22
- Number
- 5
- Start Page
- 1977
- End Page
- 1984
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/109429
- DOI
- 10.1039/c1jm14693a
- ISSN
- 0959-9428
- Abstract
- We report self-assembled polymeric nanovesicles composed of 1,4-bis{4'-[N,N-bis(6 ''-trimethylammoniumhexyl)amino]styryl}benzene tetrabromide (C1), poly[(ethylene oxide)-block-(sodium 2-acrylamido-2-methyl-1-propane sulfonate)] (E-m-A(n)), and hexadecyltrimethylammonium bromide (C-16). Transmission electron microscopy (TEM) micrographs confirm the vesicular bilayer structures and atomic force microscopy (AFM) images show that the C1/E-m-A(n)/C-16 complexes form spherical nanostructures with a particle size ranging from 40 to 80 nm. The encapsulation of C1 inside the nanovesicles enhances similar to 2-fold the fluorescence quantum yield (eta) and two-photon action cross-section (eta delta, where delta is the two-photon absorption cross-section), and allows internalization into the cells, as revealed by the bright two-photon microscopy (TPM) images of human cervical epithelioid carcinoma (HeLa) cells labeled with the nanovesicles. Moreover, nanovesicles containing a chemotherapeutic drug and a neutral molecule can also be prepared. Furthermore, the C1/vesicular complex is disassembled under acidic conditions, highlighting its potential as a pH-responsive smart nanocarrier for the intracellular drug delivery. These results suggest a new possibility of using nanovesicles as efficient two-photon probes for TPM imaging and possibly as nanocarriers for intracellular drug delivery.
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