Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Three-dimensional extracellular matrix-mediated neural stem cell differentiation in a microfluidic device
- Authors
- Han, Sewoon; Yang, Kisuk; Shin, Yoojin; Lee, Jung Seung; Kamm, Roger D.; Chung, Seok; Cho, Seung-Woo
- Issue Date
- 2012
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- LAB ON A CHIP, v.12, no.13, pp.2305 - 2308
- Indexed
- SCIE
SCOPUS
- Journal Title
- LAB ON A CHIP
- Volume
- 12
- Number
- 13
- Start Page
- 2305
- End Page
- 2308
- ISSN
- 1473-0197
- Abstract
- Here, we report a unique method to quantify the effects of in vivo-like extracellular matrix (ECM) for guiding differentiation of neural stem cells (NSCs) in three-dimensional (3D) microenvironments using quantitative real-time polymerase chain reaction (qRT-PCR). We successfully monitored and quantified differentiation of NSCs in small volume ECMs and found that differentiation of NSCs, especially those differentiating towards neuronal and oligodendrocytic lineages, is significantly enhanced by 3D microenvironments reconstituted in the microfluidic channels.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Engineering > Department of Mechanical Engineering > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.