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A versatile assay for monitoring in vivo-like transendothelial migration of neutrophils
- Authors
- Han, Sewoon; Yan, Ji-Jing; Shin, Yoojin; Jeon, Jessie S.; Won, Jihee; Jeong, Hyo Eun; Kamm, Roger D.; Kim, Young-Joon; Chung, Seok
- Issue Date
- 2012
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- LAB ON A CHIP, v.12, no.20, pp.3861 - 3865
- Indexed
- SCIE
SCOPUS
- Journal Title
- LAB ON A CHIP
- Volume
- 12
- Number
- 20
- Start Page
- 3861
- End Page
- 3865
- ISSN
- 1473-0197
- Abstract
- Spatiotemporal analysis of the inflammatory response has been limited by the difficulties of in vivo imaging and reconstitution of inflammation in vitro. Here, we present a novel method for establishing in vivo-like inflammatory models in a microfluidic device and quantitatively measuring the three-dimensional transmigration of neutrophils during the inflammatory process. This enabled us to concurrently characterize transendothelial migration behaviors of neutrophils under the influence of various inflammatory stimuli.
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Collections - College of Engineering > Department of Mechanical Engineering > 1. Journal Articles
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