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Stress and Sleep DisorderStress and Sleep Disorder

Other Titles
Stress and Sleep Disorder
Authors
한금선김린심인섭
Issue Date
2012
Publisher
한국뇌신경과학회
Keywords
stress; sleep disorders; psychological stress response
Citation
Experimental Neurobiology, v.21, no.4, pp.141 - 150
Indexed
KCI
OTHER
Journal Title
Experimental Neurobiology
Volume
21
Number
4
Start Page
141
End Page
150
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/110489
ISSN
1226-2560
Abstract
The purpose of this study was to review potential, physiological, hormonal and neuronal mechanisms that may mediate the sleep changes. This paper investigates the literatures regarding the activity of the hypothalamic-pituitary-adrenal (HPA) axis, one of the main neuroendocrine stress systems during sleep in order to identify relations between stress and sleep disorder and the treatment of stress-induced insomnia. Sleep and wakefulness are regulated by the aminergic, cholinergic brainstem and hypothalamic systems. Activation of the HPA and/or the sympathetic nervous systems results in wakefulness and these hormones including corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), cortisol or corticosterone, noradrenaline, and adrenaline, are associated with attention and arousal. Stress-related insomnia leads to a vicious circle by activating the HPA system. An awareness of the close interaction between sleep and stress systems is emerging and the hypothalamus is now recognized as a key center for sleep regulation, with hypothalamic neurontransmitter systems providing the framework for therapeutic advances. An updated understanding of these systems may allow researchers to elucidate neural mechanisms of sleep disorder and to develop effective intervention for sleep disorder.
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