The effects of hydrogen sulfide under sevoflurane administration against ischemia and reperfusion injury in isolated rat heart
- Authors
- Lee, D.K.; Lim, S.H.; Kim, N.S.
- Issue Date
- 2012
- Publisher
- Korean Society of Anesthesiologists
- Keywords
- Heart; Hydrogen sulfide; In vitro; Ischemia; Reperfusion injury; Sevoflurane
- Citation
- Korean Journal of Anesthesiology, v.62, no.5, pp.461 - 467
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Journal of Anesthesiology
- Volume
- 62
- Number
- 5
- Start Page
- 461
- End Page
- 467
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/110634
- DOI
- 10.4097/kjae.2012.62.5.461
- ISSN
- 2005-6419
- Abstract
- Background: Hydrogen sulfide (H<inf>2</inf>S) produces a protective effect against myocardial ischemia and reperfusion injury. Sevoflurane, which is used for anesthesia in cardiac problem patients, also has a protective effect. This study is designed to reveal the effects of H2S under sevoflurane using rat hearts. Methods: The hearts were Langendorff-perfused, subjected to 30 minutes ischemia and 60 minutes reperfusion. Group I was a control group. The other groups were pretreated for 15 minutes before ischemia as follows: 1.6% sevoflurane for group S; 18.5 μM H<inf>2</inf>S S for group H; and 1.6 % sevoflurane and 18.5 μM H<inf>2</inf>S simultaneously for group HS. Hemodynamics and the infarct size were measured. Results: Group HS presented depressed hemodynamics during pretreatment. LV function in group HS achieved better recovery than group I after reperfusion. The infarct size of groups S, H and HS was smaller than group I, while there were no differences between groups S, H and HS. Conclusions: Exogenous H<inf>2</inf>S did not enhance the preconditioning effects of sevoflurane. Rather, the results suggest that H<inf>2</inf>S under sevoflurane might depress hemodynamics. © the Korean Society of Anesthesiologists, 2012.
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