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Dissolution profile analysis of hydroxypropyl methylcellulose-based vitamin c tablets
- Authors
- Cha, J.H.; Hong, J.K.; Lee, S.W.; Cha, J.U.; Ko, W.H.; Back, H.H.; Park, H.J.
- Issue Date
- 2012
- Publisher
- Korean Society of Food Science and Technology
- Keywords
- HPMC; Hydroxypropyl methylcellulose; Matrix tablet; Sustained release; Vitamin C
- Citation
- Korean Journal of Food Science and Technology, v.44, no.3, pp.274 - 279
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Journal of Food Science and Technology
- Volume
- 44
- Number
- 3
- Start Page
- 274
- End Page
- 279
- ISSN
- 0367-6293
- Abstract
- The objective of this study was to develop oral matrix tablets for the sustained release of vitamin C. In this study hydroxypropyl methylcellulose (HPMC) has been utilized as an excipient, as it is one of the most widely used polymers, for use during long periods of time in formations. The vitamin C tablet formulation depends on the molecular weight and concentration of sustained-delivery in HPMC. Anti-oxidants have been added as a dissolution medium in order to prevent vitamin C degradation in water. The dissolution test was carried out in a distilled water medium, and the release model equation was applied to analyze the vitamin C release pattern. The results demonstrated that the release and lasting power of vitamin C tablets, containing HPMC, lasted for more than 12 h.
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