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Role of Nicotinic acetylcholine receptor on efferent inhibition in cochlear hair cell
- Authors
- Im, G.J.
- Issue Date
- 2012
- Keywords
- Acetylcholine; Calcium; Cochlea; Hair cell; Nicotinic receptor
- Citation
- Korean Journal of Audiology, v.16, no.3, pp.108 - 113
- Indexed
- SCOPUS
KCI
OTHER
- Journal Title
- Korean Journal of Audiology
- Volume
- 16
- Number
- 3
- Start Page
- 108
- End Page
- 113
- ISSN
- 2092-9862
- Abstract
- The α9α10 nicotinic acetylcholine receptors (nAChRs) mediates efferent inhibition of hair cell function within the auditory sensory organ. Gating of the nAChRs leads to activation of calcium-dependent potassium channels to hyperpolarize the hair cell. In efferent system, main calcium providers to SK channel are nAChR and synaptic cistern, which contribution to efferent inhibition is different between avian and mammalian species. Calcium permeation is more effective in nAChRs of mammalian cochlea than avian cochlea, and mammalian calcium permeability of nAChRs is about 3 times more than avian hair cell. Thus, mammalian nAChRs is a main component of efferent inhibition in cochlear hair cell system © 2012 The Korean Audiological Society.
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