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Site-specific incorporation of μ-N-crotonyllysine into histones
- Authors
- Kim, C.H.; Kang, M.; Kim, H.J.; Chatterjee, A.; Schultz, P.G.
- Issue Date
- 2012
- Keywords
- Crotonylations; Histones; Nonnatural amino acids; Post-translational modifications
- Citation
- Angewandte Chemie - International Edition, v.51, no.29, pp.7246 - 7249
- Indexed
- SCIE
SCOPUS
- Journal Title
- Angewandte Chemie - International Edition
- Volume
- 51
- Number
- 29
- Start Page
- 7246
- End Page
- 7249
- ISSN
- 1433-7851
- Abstract
- A novel post-translationally modified amino acid, crotonyllysine (Kcr), was genetically incorporated into proteins in bacterial and mammalian cells using an evolved pyrrolysyl-tRNA/synthetase-tRNA pair. The ability to produce histones with homogenous, site-specific Kcr modifications will be valuable in elucidating the biological role of this recently identified post-translational modification. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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