Expression of intercellular adhesion molecule-1 and E-selectin in gastric cancer and their clinical significance
DC Field | Value | Language |
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dc.contributor.author | Jung, W.-C. | - |
dc.contributor.author | Jang, Y.-J. | - |
dc.contributor.author | Kim, J.-H. | - |
dc.contributor.author | Park, S.-S. | - |
dc.contributor.author | Park, S.-H. | - |
dc.contributor.author | Kim, S.-J. | - |
dc.contributor.author | Mok, Y.-J. | - |
dc.contributor.author | Kim, C.-S. | - |
dc.date.accessioned | 2021-09-07T04:21:52Z | - |
dc.date.available | 2021-09-07T04:21:52Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 2093-582X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/110719 | - |
dc.description.abstract | Purpose: Among cell adhesion molecules, serum levels of intercellular adhesion molecule-1 and E-selectin are known to be correlated with the metastatic potential of gastric cancer. In the present study, the authors investigated the expression of intercellular adhesion molecule-1 and E-selectin in gastric cancer tissues and cultured gastric cancer cells, and examined their clinical value in gastric cancer. Materials and Methods: The protein was extracted from gastric cancer tissues and cultured gastric cancer cells (MKN-28 and Kato-III) and the expression of intercellular adhesion molecule-1 and E-selectin was examined by western blotting. The clinical significance of intercellular adhesion molecule-1 and E-selectin was explored, using immunohistochemical staining of specimens from 157 gastric cancer patients. Results: In western blot analysis, the expressions of intercellular adhesion molecule-1 in gastric cancer tissues and cultured gastric cancer cells were increased, however, E-selectin in gastric cancer tissues and cells were not increased. Among 157 gastric cancer patients, 79 patients (50%) were intercellular adhesion molecule-1 positive and had larger tumor size, an increased depth of tumor invasion, lymph node metastasis and perineural invasion. The intercellular adhesion molecule-1 positive group showed a higher incidence of tumor recurrence (40.5%), and a poorer 3-year survival than the negative group (54.9 vs. 85.9%, respectively). Conclusions: Intercellular adhesion molecule-1 is overexpressed in gastric cancer tissues and cultured gastric cancer cells, whereas E-selectin is not overexpressed. Increased expression of intercellular adhesion molecule-1 in gastric cancer could be related to the aggressive nature of the tumor, and has a poor prognostic effect on gastric cancer. © 2012 by The Korean Gastric Cancer Association. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | Korean Gastric Cancer Association | - |
dc.title | Expression of intercellular adhesion molecule-1 and E-selectin in gastric cancer and their clinical significance | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jang, Y.-J. | - |
dc.contributor.affiliatedAuthor | Kim, J.-H. | - |
dc.contributor.affiliatedAuthor | Park, S.-S. | - |
dc.contributor.affiliatedAuthor | Park, S.-H. | - |
dc.contributor.affiliatedAuthor | Kim, S.-J. | - |
dc.contributor.affiliatedAuthor | Mok, Y.-J. | - |
dc.contributor.affiliatedAuthor | Kim, C.-S. | - |
dc.identifier.doi | 10.5230/jgc.2012.12.3.140 | - |
dc.identifier.scopusid | 2-s2.0-84930483176 | - |
dc.identifier.bibliographicCitation | Journal of Gastric Cancer, v.12, no.3, pp.140 - 148 | - |
dc.relation.isPartOf | Journal of Gastric Cancer | - |
dc.citation.title | Journal of Gastric Cancer | - |
dc.citation.volume | 12 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 140 | - |
dc.citation.endPage | 148 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001699930 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
dc.subject.keywordAuthor | E-selectin | - |
dc.subject.keywordAuthor | Intercellular adhesion molecule-1 | - |
dc.subject.keywordAuthor | Stomach neoplasms | - |
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