Expression of intercellular adhesion molecule-1 and E-selectin in gastric cancer and their clinical significance
- Authors
- Jung, W.-C.; Jang, Y.-J.; Kim, J.-H.; Park, S.-S.; Park, S.-H.; Kim, S.-J.; Mok, Y.-J.; Kim, C.-S.
- Issue Date
- 2012
- Publisher
- Korean Gastric Cancer Association
- Keywords
- E-selectin; Intercellular adhesion molecule-1; Stomach neoplasms
- Citation
- Journal of Gastric Cancer, v.12, no.3, pp.140 - 148
- Indexed
- SCOPUS
KCI
OTHER
- Journal Title
- Journal of Gastric Cancer
- Volume
- 12
- Number
- 3
- Start Page
- 140
- End Page
- 148
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/110719
- DOI
- 10.5230/jgc.2012.12.3.140
- ISSN
- 2093-582X
- Abstract
- Purpose: Among cell adhesion molecules, serum levels of intercellular adhesion molecule-1 and E-selectin are known to be correlated with the metastatic potential of gastric cancer. In the present study, the authors investigated the expression of intercellular adhesion molecule-1 and E-selectin in gastric cancer tissues and cultured gastric cancer cells, and examined their clinical value in gastric cancer. Materials and Methods: The protein was extracted from gastric cancer tissues and cultured gastric cancer cells (MKN-28 and Kato-III) and the expression of intercellular adhesion molecule-1 and E-selectin was examined by western blotting. The clinical significance of intercellular adhesion molecule-1 and E-selectin was explored, using immunohistochemical staining of specimens from 157 gastric cancer patients. Results: In western blot analysis, the expressions of intercellular adhesion molecule-1 in gastric cancer tissues and cultured gastric cancer cells were increased, however, E-selectin in gastric cancer tissues and cells were not increased. Among 157 gastric cancer patients, 79 patients (50%) were intercellular adhesion molecule-1 positive and had larger tumor size, an increased depth of tumor invasion, lymph node metastasis and perineural invasion. The intercellular adhesion molecule-1 positive group showed a higher incidence of tumor recurrence (40.5%), and a poorer 3-year survival than the negative group (54.9 vs. 85.9%, respectively). Conclusions: Intercellular adhesion molecule-1 is overexpressed in gastric cancer tissues and cultured gastric cancer cells, whereas E-selectin is not overexpressed. Increased expression of intercellular adhesion molecule-1 in gastric cancer could be related to the aggressive nature of the tumor, and has a poor prognostic effect on gastric cancer. © 2012 by The Korean Gastric Cancer Association.
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