Single pretreatment of remifentanil may reduce pain after propofol and rocuronium injection in rapid sequence induction
- Authors
- Choi, Y.J.; Park, H.S.; Lee, H.; Yoon, S.Z.
- Issue Date
- 2012
- Keywords
- Injection pain; Lidocaine; Propofol; Remifentanil; Rocuronium
- Citation
- Korean Journal of Anesthesiology, v.63, no.5, pp.413 - 418
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Journal of Anesthesiology
- Volume
- 63
- Number
- 5
- Start Page
- 413
- End Page
- 418
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/110736
- DOI
- 10.4097/kjae.2012.63.5.413
- ISSN
- 2005-6419
- Abstract
- Background: We designed this double-blind, placebo-controlled study to compare the efficacy of remifentanil in reducing the pain of both propofol and rocuronium injection during rapid-sequence induction. Methods: Ninety-five patients, scheduled for elective surgery under general anesthesia, were divided into 3 groups: saline (Group S, n = 31), remifentanil 1 μg/kg (Group R, n = 32), and lidocaine 1.5 mg/kg (Group L, n = 32) were administered after tourniquet application. The occlusion was released after 1 min and 5 ml of 1% propofol was injected over 10 s. Pain on propofol injection was evaluated by a 10-point verbal numeric rating scale (VNRS). The rest of the induction dose of propofol and 1 mg/kg of rocuronium, were injected. Pain on rocuronium injection was evaluated by a four-point score (FPS). Results: The VNRS of propofol injection was as follows: R (0.78) = L (1.34) < S (4.26). The incidence of withdrawal response due to rocuronium was as follows: R (6.3%) < L (53.1%) < S (83.9%). The FPS of rocuronium injection was as follows: R (0.81) < L (1.78) < S (2.93). Conclusions: Pretreatment with a bolus of remifentanil was effective in simultaneously reducing injection pain of propofol and rocuronium. In addition, remifentanil pretreatment was more effective in suppression of withdrawal response by rocuronium than lidocaine. © the Korean Society of Anesthesiologists, 2012.
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