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Fluorescent turn-on Zn2+ sensing in aqueous and cellular media
- Authors
- Lee, Sumin; Lee, Jae Hong; Pradhan, Tuhin; Lim, Chang Su; Cho, Bong Rae; Bhuniya, Sankarprasad; Kim, Sungtae; Kim, Jong Seung
- Issue Date
- 15-12월-2011
- Publisher
- ELSEVIER SCIENCE SA
- Keywords
- Zinc; Fluorescent sensor; Cell imaging; DFT calculations
- Citation
- SENSORS AND ACTUATORS B-CHEMICAL, v.160, no.1, pp.1489 - 1493
- Indexed
- SCIE
SCOPUS
- Journal Title
- SENSORS AND ACTUATORS B-CHEMICAL
- Volume
- 160
- Number
- 1
- Start Page
- 1489
- End Page
- 1493
- ISSN
- 0925-4005
- Abstract
- A naphthalimide-based water soluble Zn2+ sensor bearing polyamino carboxylate as a metal chelating moiety was synthesized and its application for the selective detection of Zn2+ ion in 100% aqueous solution is demonstrated. The newly developed fluorescent sensor exhibits selective binding affinity towards Zn2+ and pH insensitivity in biologically relevant range. Confocal fluorescent microscopy images indicate that this probe works effectively for intracellular Zn2+ imaging with high cell permeability. (C) 2011 Elsevier B.V. All rights reserved.
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