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Expedient synthesis of 4-O-methylhonokiol via Suzuki-Miyaura cross-coupling

Authors
Kwak, Jae-HwanCho, Young AeJang, Jae-YongSeo, Seung-YongLee, HeesoonHong, Jin TaeHan, Sang-BaeLee, KihoKwak, Young-ShinJung, Jae-Kyung
Issue Date
2-Dec-2011
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
Neolignan; 4-O-Methylhonokiol; Suzuki-Miyaura cross-coupling; Potassium aryltrifluoroborate
Citation
TETRAHEDRON, v.67, no.48, pp.9401 - 9404
Indexed
SCIE
SCOPUS
Journal Title
TETRAHEDRON
Volume
67
Number
48
Start Page
9401
End Page
9404
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/110926
DOI
10.1016/j.tet.2011.09.115
ISSN
0040-4020
Abstract
Concise and practical synthesis of 4-O-methylhonokiol was achieved in 34% overall yield. The key features of our synthesis include chemoselective ortho-mono bromination of phenol as well as biaryl formation via Suzuki-Miyaura cross-coupling, in which bromophenol was reacted with potassium aryltrifluoroborate using Pd(OAc)(2) and RuPhos under microwave conditions. (C) 2011 Elsevier Ltd. All rights reserved.
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