Effect of Helicobacter pylori Eradication on the Development of Reflux Esophagitis and Gastroesophageal Reflux Symptoms: A Nationwide MultiCenter Prospective Study
- Authors
- Kim, Nayoung; Lee, Sang Woo; Kim, Jin Il; Baik, Gwang Ho; Kim, Sung Jung; Seo, Geom Seog; Oh, Hyo Jeong; Kim, Sang Wook; Jeong, Heyjin; Hong, Su Jin; Shim, Ki-Nam; Shin, Jeong Eun; Park, Seun Ja; Im, Eui Hyeog; Park, Jong-Jae; Cho, Sung-Il; Jung, Hyun Chae
- Issue Date
- 12월-2011
- Publisher
- EDITORIAL OFFICE GUT & LIVER
- Keywords
- Helicobacter pylori; Eradication; Reflux esophagitis; Symptoms
- Citation
- GUT AND LIVER, v.5, no.4, pp.437 - 446
- Indexed
- SCIE
SCOPUS
KCI
OTHER
- Journal Title
- GUT AND LIVER
- Volume
- 5
- Number
- 4
- Start Page
- 437
- End Page
- 446
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/110965
- DOI
- 10.5009/gnl.2011.5.4.437
- ISSN
- 1976-2283
- Abstract
- Background/Aims: A two-year, prospective, nationwide multicenter study was undertaken to evaluate the effect of Helicobacter pylori eradication on the development of reflux esophagitis (RE) and gastroesophageal reflux disease (GERD) symptoms in the Korean population. Methods: In total, 1,489 subjects without RE were enrolled at the outpatient clinics of 12 tertiary hospitals nationwide, and 452 subjects underwent follow-up (F/U) for 2 years to evaluate the development of RE and GERD symptoms. Results: RE was found in 33 subjects (7.3% of 452 subjects) and 14 subjects (7.3% of 192 subjects) during the first and second year of F/U, respectively. H. pylori status was not associated with the development of RE. RE was found in six (9.0%) of 67 H. pylorinegative patients, in 26 (11.2%) of 233 eradicated subjects and in eight (7.0%) of 114 noneradicated subjects (p=0.532). Multivariate analysis showed that age >= 60 years (odds ratio [OR], 7.11; 95% confidence interval [Cl], 1.92 to 26.41), alcohol consumption (OR, 4.43; 95% Cl, 1.03 to 19.19) and F/U cholesterol levels >= 200 mg/dL (OR, 5.03; 95% Cl, 1.32 to 19.17) were significant risk factors for the development of RE. There was no significant difference in the development of GERD symptoms or weight according to H. pylori status during the 2-year F/U. Conclusions: Eradication of H. pylori did not affect the development of reflux esophagitis or GERD symptoms among patients in outpatient gastroenterology clinics in South Korea. (Gut Liver 2011;5:437-446)
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.