Effect of anthocyanins on expression of matrix metalloproteinase-2 in naproxen-induced gastric ulcers
DC Field | Value | Language |
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dc.contributor.author | Kim, Sun-Joong | - |
dc.contributor.author | Park, Young Sam | - |
dc.contributor.author | Paik, Hyun-Dong | - |
dc.contributor.author | Chang, Hyo Ihl | - |
dc.date.accessioned | 2021-09-07T05:36:14Z | - |
dc.date.available | 2021-09-07T05:36:14Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2011-12 | - |
dc.identifier.issn | 0007-1145 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111021 | - |
dc.description.abstract | Non-steroidal anti-inflammatory drugs cause gastric ulceration through a number of mechanisms including inhibition of PG synthesis, generation of reactive oxygen species (ROS) and induction of apoptosis. Recently, matrix metalloproteinases (MMP) have been suggested to play a crucial role in these mechanisms. The present study investigated the protective effect of anthocyanins isolated from black rice bran (Heugjinjubyeo) against naproxen-induced gastric mucosal injury in rats. The oral administration of anthocyanins (5, 25 or 50 mg/kg body weight) showed significant protection against naproxen (80 mg/kg body weight)-induced gastric ulcer and inhibited lipid peroxidation in the gastric mucosa. In addition, pretreatment with anthocyanins resulted in a significant increase in the activities of radical-scavenging enzymes such as superoxide dismutase, catalase and glutathione peroxidase. Also biochemical and zymographic analyses suggested that the administration of anthocyanins gives a significant protection against naproxen-induced gastric antral ulcer through scavenging ROS and regulation of matrix metalloproteinase-2 (MMP-2) activity. The results of intracellular radical activation show that anthocyanins suppress the generation of intracellular ROS and attenuate the suppression of MMP-2 activity by naproxen. These results suggest that anthocyanins extracted from black rice may offer potential remedy of gastric antral ulceration. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CAMBRIDGE UNIV PRESS | - |
dc.subject | LIPID-PEROXIDATION | - |
dc.subject | MUCOSAL INJURY | - |
dc.subject | INDOMETHACIN | - |
dc.subject | MATRIX-METALLOPROTEINASE-9 | - |
dc.subject | PATHOGENESIS | - |
dc.subject | INFLAMMATION | - |
dc.subject | PREVENTION | - |
dc.subject | ASPIRIN | - |
dc.title | Effect of anthocyanins on expression of matrix metalloproteinase-2 in naproxen-induced gastric ulcers | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chang, Hyo Ihl | - |
dc.identifier.doi | 10.1017/S000711451100242X | - |
dc.identifier.scopusid | 2-s2.0-80053908177 | - |
dc.identifier.wosid | 000298111400003 | - |
dc.identifier.bibliographicCitation | BRITISH JOURNAL OF NUTRITION, v.106, no.12, pp.1792 - 1801 | - |
dc.relation.isPartOf | BRITISH JOURNAL OF NUTRITION | - |
dc.citation.title | BRITISH JOURNAL OF NUTRITION | - |
dc.citation.volume | 106 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1792 | - |
dc.citation.endPage | 1801 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | MUCOSAL INJURY | - |
dc.subject.keywordPlus | INDOMETHACIN | - |
dc.subject.keywordPlus | MATRIX-METALLOPROTEINASE-9 | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | ASPIRIN | - |
dc.subject.keywordAuthor | Anthocyanins | - |
dc.subject.keywordAuthor | Gastric ulcers | - |
dc.subject.keywordAuthor | Matrix metalloproteinase | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
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