Effect of anthocyanins on expression of matrix metalloproteinase-2 in naproxen-induced gastric ulcers
- Authors
- Kim, Sun-Joong; Park, Young Sam; Paik, Hyun-Dong; Chang, Hyo Ihl
- Issue Date
- 12월-2011
- Publisher
- CAMBRIDGE UNIV PRESS
- Keywords
- Anthocyanins; Gastric ulcers; Matrix metalloproteinase; Reactive oxygen species
- Citation
- BRITISH JOURNAL OF NUTRITION, v.106, no.12, pp.1792 - 1801
- Indexed
- SCIE
SCOPUS
- Journal Title
- BRITISH JOURNAL OF NUTRITION
- Volume
- 106
- Number
- 12
- Start Page
- 1792
- End Page
- 1801
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/111021
- DOI
- 10.1017/S000711451100242X
- ISSN
- 0007-1145
- Abstract
- Non-steroidal anti-inflammatory drugs cause gastric ulceration through a number of mechanisms including inhibition of PG synthesis, generation of reactive oxygen species (ROS) and induction of apoptosis. Recently, matrix metalloproteinases (MMP) have been suggested to play a crucial role in these mechanisms. The present study investigated the protective effect of anthocyanins isolated from black rice bran (Heugjinjubyeo) against naproxen-induced gastric mucosal injury in rats. The oral administration of anthocyanins (5, 25 or 50 mg/kg body weight) showed significant protection against naproxen (80 mg/kg body weight)-induced gastric ulcer and inhibited lipid peroxidation in the gastric mucosa. In addition, pretreatment with anthocyanins resulted in a significant increase in the activities of radical-scavenging enzymes such as superoxide dismutase, catalase and glutathione peroxidase. Also biochemical and zymographic analyses suggested that the administration of anthocyanins gives a significant protection against naproxen-induced gastric antral ulcer through scavenging ROS and regulation of matrix metalloproteinase-2 (MMP-2) activity. The results of intracellular radical activation show that anthocyanins suppress the generation of intracellular ROS and attenuate the suppression of MMP-2 activity by naproxen. These results suggest that anthocyanins extracted from black rice may offer potential remedy of gastric antral ulceration.
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Collections - College of Life Sciences and Biotechnology > Division of Life Sciences > 1. Journal Articles
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