A Combination of Grape Extract, Green Tea Extract and L-Carnitine Improves High-fat Diet-induced Obesity, Hyperlipidemia and Non-alcoholic Fatty Liver Disease in Mice
DC Field | Value | Language |
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dc.contributor.author | Kang, Jong Soon | - |
dc.contributor.author | Lee, Won Kyung | - |
dc.contributor.author | Yoon, Won Kee | - |
dc.contributor.author | Kim, Nayang | - |
dc.contributor.author | Park, Sang-Ki | - |
dc.contributor.author | Park, Hyoung Kook | - |
dc.contributor.author | Ly, Sun Yung | - |
dc.contributor.author | Han, Sang-Bae | - |
dc.contributor.author | Yun, Jieun | - |
dc.contributor.author | Lee, Chang Woo | - |
dc.contributor.author | Lee, Kiho | - |
dc.contributor.author | Lee, Ki Hoon | - |
dc.contributor.author | Park, Song-Kyu | - |
dc.contributor.author | Kim, Hwan Mook | - |
dc.date.accessioned | 2021-09-07T05:45:32Z | - |
dc.date.available | 2021-09-07T05:45:32Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2011-12 | - |
dc.identifier.issn | 0951-418X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111073 | - |
dc.description.abstract | To develop a therapeutic agent for obesity-related metabolic disorders, a mixture of dietary components was prepared, including grape extract, green tea extract and L-carnitine (RGTC), and its effects on obesity, hyperlipidemia and non-alcoholic fatty liver disease examined. The RGTC dramatically inhibited the high-fat diet (HFD)-induced increase in body weight and fat in C57BL/6 mice, whereas food consumption was not affected by RGTC treatment. The RGTC also concentration-dependently suppressed the HFD-induced increase in plasma lipids, such as low-density lipoprotein cholesterol and triglycerides. In addition, increases in liver weight and liver steatosis were returned to normal by RGTC treatment in HFD-fed C57BL/6 mice. The plasma levels of glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase were also significantly down-regulated by RGTC treatment. These results suggest that RGTC suppressed HFD-induced obesity, hyperlipidemia and non-alcoholic fatty liver disease, suggesting that RGTC supplementation might be a promising adjuvant therapy for the treatment of these metabolic disorders. Copyright (C) 2011 John Wiley & Sons, Ltd. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | 3T3-L1 ADIPOCYTES | - |
dc.subject | METABOLIC SYNDROME | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | RESVERATROL | - |
dc.subject | CATECHINS | - |
dc.subject | CAFFEINE | - |
dc.subject | ADIPOGENESIS | - |
dc.subject | POLYPHENOLS | - |
dc.subject | INHIBITION | - |
dc.subject | QUERCETIN | - |
dc.title | A Combination of Grape Extract, Green Tea Extract and L-Carnitine Improves High-fat Diet-induced Obesity, Hyperlipidemia and Non-alcoholic Fatty Liver Disease in Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kiho | - |
dc.contributor.affiliatedAuthor | Park, Song-Kyu | - |
dc.identifier.doi | 10.1002/ptr.3476 | - |
dc.identifier.scopusid | 2-s2.0-82155201715 | - |
dc.identifier.wosid | 000298277900009 | - |
dc.identifier.bibliographicCitation | PHYTOTHERAPY RESEARCH, v.25, no.12, pp.1789 - 1795 | - |
dc.relation.isPartOf | PHYTOTHERAPY RESEARCH | - |
dc.citation.title | PHYTOTHERAPY RESEARCH | - |
dc.citation.volume | 25 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1789 | - |
dc.citation.endPage | 1795 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | 3T3-L1 ADIPOCYTES | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | RESVERATROL | - |
dc.subject.keywordPlus | CATECHINS | - |
dc.subject.keywordPlus | CAFFEINE | - |
dc.subject.keywordPlus | ADIPOGENESIS | - |
dc.subject.keywordPlus | POLYPHENOLS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | QUERCETIN | - |
dc.subject.keywordAuthor | grape extract | - |
dc.subject.keywordAuthor | green tea extract | - |
dc.subject.keywordAuthor | L-carnitine | - |
dc.subject.keywordAuthor | high-fat diet | - |
dc.subject.keywordAuthor | hyperlipidemia | - |
dc.subject.keywordAuthor | fatty liver disease | - |
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