A Combination of Grape Extract, Green Tea Extract and L-Carnitine Improves High-fat Diet-induced Obesity, Hyperlipidemia and Non-alcoholic Fatty Liver Disease in Mice
- Authors
- Kang, Jong Soon; Lee, Won Kyung; Yoon, Won Kee; Kim, Nayang; Park, Sang-Ki; Park, Hyoung Kook; Ly, Sun Yung; Han, Sang-Bae; Yun, Jieun; Lee, Chang Woo; Lee, Kiho; Lee, Ki Hoon; Park, Song-Kyu; Kim, Hwan Mook
- Issue Date
- 12월-2011
- Publisher
- WILEY
- Keywords
- grape extract; green tea extract; L-carnitine; high-fat diet; hyperlipidemia; fatty liver disease
- Citation
- PHYTOTHERAPY RESEARCH, v.25, no.12, pp.1789 - 1795
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHYTOTHERAPY RESEARCH
- Volume
- 25
- Number
- 12
- Start Page
- 1789
- End Page
- 1795
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/111073
- DOI
- 10.1002/ptr.3476
- ISSN
- 0951-418X
- Abstract
- To develop a therapeutic agent for obesity-related metabolic disorders, a mixture of dietary components was prepared, including grape extract, green tea extract and L-carnitine (RGTC), and its effects on obesity, hyperlipidemia and non-alcoholic fatty liver disease examined. The RGTC dramatically inhibited the high-fat diet (HFD)-induced increase in body weight and fat in C57BL/6 mice, whereas food consumption was not affected by RGTC treatment. The RGTC also concentration-dependently suppressed the HFD-induced increase in plasma lipids, such as low-density lipoprotein cholesterol and triglycerides. In addition, increases in liver weight and liver steatosis were returned to normal by RGTC treatment in HFD-fed C57BL/6 mice. The plasma levels of glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase were also significantly down-regulated by RGTC treatment. These results suggest that RGTC suppressed HFD-induced obesity, hyperlipidemia and non-alcoholic fatty liver disease, suggesting that RGTC supplementation might be a promising adjuvant therapy for the treatment of these metabolic disorders. Copyright (C) 2011 John Wiley & Sons, Ltd.
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