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Inhibitory effect on NO production of phenolic compounds from Myristica fragrans
- Authors
- Cuong, To Dao; Hung, Tran Manh; Na, MinKyun; Do Thi Ha; Kim, Jin Cheol; Lee, Dongho; Ryoo, SungWoo; Lee, Jeong Hyung; Choi, Jae Sue; Min, Byung Sun
- Issue Date
- 15-11월-2011
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Myristica fragrans; Myristicaceae; Phenolic; Anti-inflammatory activity
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.21, no.22, pp.6884 - 6887
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 21
- Number
- 22
- Start Page
- 6884
- End Page
- 6887
- ISSN
- 0960-894X
- Abstract
- Three new phenolics: ((7S)-8'-(benzo[3',4']dioxol-1'-yl)-7-hydroxypropyl)benzene-2,4-diol (1), ((7S)-8'- (4'-hydroxy-3'-methoxyphenyl)-7-hydroxypropyl)benzene-2,4-diol (2) and ((8R,8'S)-7-(4-hydroxy-3-methoxyphenyl)-8'-methylbutan-8-yl)-3'-methoxybenzene-4',5'-diol (3), along with four known compounds (4-7) were isolated from the seeds of Myristica fragrans. Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against LPS-induced NO production in macrophage RAW264.7 cells. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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